Pxn - paxillin Gene

Also Known as Pax

Species: Mus musculus

Gene Type: protein coding
Gene ID: 19303

Summary

Enables BH4 domain binding activity; MAP-kinase scaffold activity; and neuropilin binding activity. Involved in positive regulation of angiogenesis and transforming growth factor beta receptor signaling pathway. Acts upstream of or within several processes, including focal adhesion assembly; integrin-mediated signaling pathway; and substrate adhesion-dependent cell spreading. Located in focal adhesion and lamellipodium. Is expressed in several structures, including early conceptus; genitourinary system; immune system; inner ear; and telencephalon. Orthologous to human PXN (paxillin). [provided by Alliance of Genome Resources, Apr 2022]

Pxn Products (7)

mRNA Protein Name
NM_001403066.1 NP_001389995.1 paxillin isoform 3
NM_001403067.1 NP_001389996.1 paxillin isoform 4
NM_001403068.1 NP_001389997.1 paxillin isoform 5
NM_001403069.1 NP_001389998.1 paxillin isoform 5
NM_001403070.1 NP_001389999.1 paxillin isoform 5
NM_011223.4 NP_035353.1 paxillin isoform alpha
NM_133915.4 NP_598676.2 paxillin isoform beta

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables BH4 domain binding IPI
IPI: Inferred from physical interaction
14699151 MGI
enables MAP-kinase scaffold activity IDA
IDA: Inferred from direct assay
14636584 MGI
enables neuropilin binding IPI
IPI: Inferred from physical interaction
24863063 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
9418872 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within branching morphogenesis of an epithelial tube IDA
IDA: Inferred from direct assay
14636584 MGI
acts upstream of or within cell migration IMP
IMP: Inferred from mutant phenotype
11784865 MGI
acts upstream of or within cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
11784865 MGI
acts upstream of or within focal adhesion assembly IDA
IDA: Inferred from direct assay
14636584 MGI
acts upstream of or within integrin-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
11784865 MGI
acts upstream of or within lamellipodium assembly IDA
IDA: Inferred from direct assay
14636584 MGI
acts upstream of or within peptidyl-tyrosine phosphorylation IDA
IDA: Inferred from direct assay
15467718 MGI
involved in positive regulation of angiogenesis IMP
IMP: Inferred from mutant phenotype
24863063 MGI
acts upstream of or within positive regulation of protein kinase activity IMP
IMP: Inferred from mutant phenotype
23658024 MGI
acts upstream of or within regulation of cell shape IMP
IMP: Inferred from mutant phenotype
23658024 MGI
acts upstream of or within substrate adhesion-dependent cell spreading IMP
IMP: Inferred from mutant phenotype
23658024 MGI
involved in transforming growth factor beta receptor signaling pathway IDA
IDA: Inferred from direct assay
24036928 MGI
Cellular Component GO Annotation Evidence References Source
located in cell leading edge IDA
IDA: Inferred from direct assay
18794329 MGI
located in focal adhesion IDA
IDA: Inferred from direct assay
10809671 MGI
located in lamellipodium IDA
IDA: Inferred from direct assay
14636584 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

paxillin

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11479 PXDN Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11484 PXN Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17322 Pxn Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23777 Pxn Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pxn NCBI NCBI:5829