Rad21 - RAD21 cohesin complex component Gene

Also Known as SCC1; mHR21; mKIAA0078

Species: Mus musculus

Gene Type: protein coding
Gene ID: 19357

Summary

Predicted to enable chromatin binding activity. Involved in negative regulation of G2/M transition of mitotic cell cycle and negative regulation of mitotic metaphase/anaphase transition. Located in chromatin; chromosome, centromeric region; and condensed nuclear chromosome. Part of cohesin complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in Cornelia de Lange syndrome 4; hepatocellular carcinoma; and lung non-small cell carcinoma. Orthologous to human RAD21 (RAD21 cohesin complex component). [provided by Alliance of Genome Resources, Apr 2022]

Rad21 Products (2)

mRNA Protein Name
NM_001411716.1 NP_001398645.1 double-strand-break repair protein rad21 homolog
NM_009009.5 NP_033035.3 double-strand-break repair protein rad21 homolog

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
28636939 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
10375619 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within chromatin looping IMP
IMP: Inferred from mutant phenotype
32328639 MGI
involved in negative regulation of G2/M transition of mitotic cell cycle IMP
IMP: Inferred from mutant phenotype
10375619 MGI
involved in negative regulation of mitotic metaphase/anaphase transition IMP
IMP: Inferred from mutant phenotype
10375619 MGI
Cellular Component GO Annotation Evidence References Source
located in chromatin IDA
IDA: Inferred from direct assay
23920377 MGI
located in chromosome, centromeric region IDA
IDA: Inferred from direct assay
26919979 MGI
part of cohesin complex IDA
IDA: Inferred from direct assay
10375619 MGI
located in condensed nuclear chromosome IDA
IDA: Inferred from direct assay
24797475 MGI
located in nucleus IDA
IDA: Inferred from direct assay
10375619 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

double-strand-break repair protein rad21 homolog

  • PW29

  • RAD21 homolog

  • SCC1 homolog

  • pokeweed agglutinin-binding protein 29

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11599 RAD21 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-P10931F RAD21 (356–395), biotin labeled / Unkown
HY-RS20093 Rad21 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26596 Rad21 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rad21 NCBI NCBI:5885