Upf1 - UPF1 regulator of nonsense transcripts homolog (yeast) Gene

Also Known as NORF1; Rent1; Upflp; PNORF-1; B430202H16Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 19704

Summary

Predicted to enable RNA helicase activity; chromatin binding activity; and nucleic acid binding activity. Acts upstream of or within dosage compensation by inactivation of X chromosome. Predicted to be located in chromatin; chromosome, telomeric region; and nucleoplasm. Predicted to be part of exon-exon junction complex and supraspliceosomal complex. Predicted to be active in cytoplasm. Is expressed in cerebral cortex ventricular layer; embryo; and oocyte. Orthologous to human UPF1 (UPF1 RNA helicase and ATPase). [provided by Alliance of Genome Resources, Apr 2022]

Upf1 Products (2)

mRNA Protein Name
NM_001122829.2 NP_001116301.1 regulator of nonsense transcripts 1 isoform a
NM_030680.3 NP_109605.2 regulator of nonsense transcripts 1 isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
23202588 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within positive regulation of mRNA cis splicing, via spliceosome IMP
IMP: Inferred from mutant phenotype
16789828 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

regulator of nonsense transcripts 1

  • ATP-dependent helicase RENT1

  • regulator of nonsense transcripts 1 (Nonsense mRNA reducing factor 1) (NORF1) (Up-frameshift suppressor 1 homolog)

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-111374 NMDI14 Modulator 99.68% Unkown
HY-124719 hSMG-1 inhibitor 11j Inhibitor 99.82% Unkown
HY-RS15482 UPF1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24987 Upf1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18505 Upf1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Upf1 NCBI NCBI:5976