Robo1 - roundabout guidance receptor 1 Gene

Also Known as DUTT1; Gm310

Species: Mus musculus

Gene Type: protein coding
Gene ID: 19876

Summary

Predicted to enable LRR domain binding activity; axon guidance receptor activity; and identical protein binding activity. Involved in several processes, including circulatory system development; neuron development; and regulation of gene expression. Acts upstream of or within animal organ development; axon guidance; and negative regulation of cell population proliferation. Located in axolemma. Is expressed in several structures, including central nervous system; foot; genitourinary system; jaw; and sensory organ. Used to study cystic kidney disease and lung Cancer. Orthologous to human ROBO1 (roundabout guidance receptor 1). [provided by Alliance of Genome Resources, Apr 2022]

Robo1 Products (1)

mRNA Protein Name
NM_019413.2 NP_062286.2 roundabout homolog 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
19684588 MGI
Biological Process GO Annotation Evidence References Source
involved in aorta development IGI
IGI: Inferred from genetic interaction
25691540 MGI
involved in aortic valve morphogenesis IGI
IGI: Inferred from genetic interaction
25691540 MGI
acts upstream of or within axon guidance IMP
IMP: Inferred from mutant phenotype
15084255 MGI
involved in axon midline choice point recognition IGI
IGI: Inferred from genetic interaction
18986510 MGI
acts upstream of or within coronary vasculature development IMP
IMP: Inferred from mutant phenotype
25807483 MGI
involved in endocardial cushion formation IGI
IGI: Inferred from genetic interaction
25691540 MGI
acts upstream of or within heart development IMP
IMP: Inferred from mutant phenotype
25807483 MGI
involved in heart induction IDA
IDA: Inferred from direct assay
25691540 MGI
acts upstream of or within kidney development IMP
IMP: Inferred from mutant phenotype
27002738 MGI
acts upstream of or within mammary duct terminal end bud growth IMP
IMP: Inferred from mutant phenotype
16439476 MGI
acts upstream of or within negative regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
18829537 MGI
involved in negative regulation of gene expression IDA
IDA: Inferred from direct assay
25691540 MGI
involved in olfactory bulb interneuron development IGI
IGI: Inferred from genetic interaction
17360927 MGI
involved in outflow tract septum morphogenesis IGI
IGI: Inferred from genetic interaction
25691540 MGI
involved in positive regulation of Notch signaling pathway IDA
IDA: Inferred from direct assay
25691540 MGI
involved in positive regulation of gene expression IDA
IDA: Inferred from direct assay
25691540 MGI
involved in pulmonary valve morphogenesis IGI
IGI: Inferred from genetic interaction
25691540 MGI
acts upstream of or within ventricular septum development IMP
IMP: Inferred from mutant phenotype
25807483 MGI
involved in ventricular septum morphogenesis IGI
IGI: Inferred from genetic interaction
25691540 MGI
Cellular Component GO Annotation Evidence References Source
located in axolemma IDA
IDA: Inferred from direct assay
15084255 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

roundabout homolog 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-175200 DEL-S1 Ligand 98.50% Unkown
HY-RS12110 ROBO1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20096 Robo1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26599 Robo1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Robo1 NCBI NCBI:6091