Rora - RAR-related orphan receptor alpha Gene

Also Known as sg; ROR1; ROR2; ROR3; Nr1f1; nmf267; tmgc26; staggerer; 9530021D13Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 19883

About Rora

Chromosome 9: 68,561,068-69,295,528 forward strand.GRCm39:CM001002.3

This gene has 6 transcripts (splice variants), 395 orthologues, 19 paralogues and is associated with 104 phenotypes. Broad expression in cerebellum adult (RPKM 8.5), cortex adult (RPKM 3.) and 19 other tissues.

Summary

The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The encoded protein has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, as well as with NM23-1, the product of a tumor metastasis suppressor candidate gene. Also, it has been shown to aid in the transcriptional regulation of some genes involved in circadian rhythm. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]

Rora Products (3)

mRNA Protein Name
NM_001289917.1 NP_001276846.1 nuclear receptor ROR-alpha isoform 3
NM_013646.2 NP_038674.1 nuclear receptor ROR-alpha isoform 1
NM_001289916.1 NP_001276845.1 nuclear receptor ROR-alpha isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
7838158 MGI
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
7838156 MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
18164222 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
15199055 MGI
enables beta-catenin binding IPI
IPI: Inferred from physical interaction
14687547 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
17110330 MGI
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
18055760 MGI
enables transcription coactivator binding IPI
IPI: Inferred from physical interaction
17476214 MGI
Biological Process GO Annotation Evidence References Source
involved in T-helper 17 cell differentiation IMP
IMP: Inferred from mutant phenotype
18164222 MGI
acts upstream of or within cGMP metabolic process IMP
IMP: Inferred from mutant phenotype
7518067 MGI
acts upstream of or within cellular response to interleukin-1 IDA
IDA: Inferred from direct assay
19955433 MGI
acts upstream of or within cellular response to tumor necrosis factor IDA
IDA: Inferred from direct assay
19955433 MGI
acts upstream of or within cerebellar Purkinje cell differentiation IMP
IMP: Inferred from mutant phenotype
8996814 MGI
involved in cerebellar granule cell precursor proliferation IMP
IMP: Inferred from mutant phenotype
14687547 MGI
involved in cholesterol homeostasis IMP
IMP: Inferred from mutant phenotype
18055760 MGI
involved in circadian regulation of gene expression IDA
IDA: Inferred from direct assay
22753030 MGI
involved in negative regulation of fat cell differentiation IMP
IMP: Inferred from mutant phenotype
19324970 MGI
acts upstream of or within nitric oxide biosynthetic process IMP
IMP: Inferred from mutant phenotype
7518067 MGI
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
21628546 MGI
involved in positive regulation of circadian rhythm IDA
IDA: Inferred from direct assay
22753030 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
15199055 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
15199055 MGI
acts upstream of or within regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
7838156 MGI
involved in regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
18055760 MGI
involved in regulation of circadian rhythm IMP
IMP: Inferred from mutant phenotype
23172836 MGI
involved in regulation of glucose metabolic process IMP
IMP: Inferred from mutant phenotype
19965867 MGI
acts upstream of or within regulation of macrophage activation IMP
IMP: Inferred from mutant phenotype
1565842 MGI
involved in regulation of smoothened signaling pathway IMP
IMP: Inferred from mutant phenotype
14687547 MGI
involved in regulation of steroid metabolic process IMP
IMP: Inferred from mutant phenotype
17666523 MGI
involved in regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
18164222 MGI
involved in regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
19324970 MGI
involved in triglyceride homeostasis IMP
IMP: Inferred from mutant phenotype
11053433 MGI
involved in xenobiotic metabolic process IMP
IMP: Inferred from mutant phenotype
17666523 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
18055760 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Rora Protein Structure

NR_DBD_ROR

NR_DBD_ROR: cd06968 (65 - 159)

NR_LBD_ROR_like

NR_LBD_ROR_like: cd06939 (271 - 510)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 523 a.a.
Protein Preferred Names Protein Names

nuclear receptor ROR-alpha

  • RAR-related orphan receptor A

  • nuclear receptor RZR-alpha

  • nuclear receptor subfamily 1 group F member 1

  • retinoid-related orphan receptor-alpha

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-402601 Desethyl-SID 7969543 Control 98.83% Unkown
HY-RS12126 RORA Human Pre-designed siRNA Set A / Unkown
HY-RS12127 Rora Mouse Pre-designed siRNA Set A / Unkown
HY-RS12128 RORA Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rora NCBI NCBI:6095