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  3. Rora - RAR-related orphan receptor alpha Gene

Rora - RAR-related orphan receptor alpha Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as sg; ROR1; ROR2; ROR3; Nr1f1; nmf267; tmgc26; staggerer; 9530021D13Rik

Gene ID: 19883 | Gene type: protein coding

About Rora

Chromosome 9: 68,561,068-69,295,528 forward strand.GRCm39:CM001002.3

This gene has 6 transcripts (splice variants), 395 orthologues, 19 paralogues and is associated with 104 phenotypes. Broad expression in cerebellum adult (RPKM 8.5), cortex adult (RPKM 3.) and 19 other tissues.

Summary

The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The encoded protein has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, as well as with NM23-1, the product of a tumor metastasis suppressor candidate gene. Also, it has been shown to aid in the transcriptional regulation of some genes involved in circadian rhythm. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]

Rora Products(3)

mRNA Protein Name
NM_001289917.1 NP_001276846.1 nuclear receptor ROR-alpha isoform 3
NM_013646.2 NP_038674.1 nuclear receptor ROR-alpha isoform 1
NM_001289916.1 NP_001276845.1 nuclear receptor ROR-alpha isoform 2

Rora Protein Structure

NR_DBD_ROR

NR_DBD_ROR: cd06968 (65 - 159)

NR_LBD_ROR_like

NR_LBD_ROR_like: cd06939 (271 - 510)

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  • 523 a.a.
Protein Preferred Names Protein Names

nuclear receptor ROR-alpha

RAR-related orphan receptor A

nuclear receptor RZR-alpha

nuclear receptor subfamily 1 group F member 1

retinoid-related orphan receptor-alpha

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS12126 RORA Human Pre-designed siRNA Set A / Unkown
HY-RS12127 Rora Mouse Pre-designed siRNA Set A / Unkown
HY-RS12128 RORA Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rora NCBI NCBI:6095