Prrx2 - paired related homeobox 2 Gene

Also Known as S8; Prx2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20204

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; HMG box domain binding activity; and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including embryonic morphogenesis; positive regulation of mesenchymal cell proliferation; and positive regulation of smoothened signaling pathway. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; brain; branchial arch; embryo mesenchyme; and genitourinary system. Orthologous to human PRRX2 (paired related homeobox 2). [provided by Alliance of Genome Resources, Apr 2022]

Prrx2 Products (1)

mRNA Protein Name
NM_009116.2 NP_033142.2 paired mesoderm homeobox protein 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific IMP
IMP: Inferred from mutant phenotype
12713735 MGI
enables HMG box domain binding IPI
IPI: Inferred from physical interaction
16582099 MGI
enables RNA polymerase II general transcription initiation factor activity IDA
IDA: Inferred from direct assay
32188878 MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IMP
IMP: Inferred from mutant phenotype
12713735 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within artery morphogenesis IGI
IGI: Inferred from genetic interaction
10664157 MGI
acts upstream of or within cartilage development IGI
IGI: Inferred from genetic interaction
9876178 MGI
acts upstream of or within embryonic cranial skeleton morphogenesis IGI
IGI: Inferred from genetic interaction
9729491 MGI
acts upstream of or within embryonic limb morphogenesis IGI
IGI: Inferred from genetic interaction
9729491 MGI
acts upstream of or within embryonic skeletal system morphogenesis IGI
IGI: Inferred from genetic interaction
9729491 MGI
acts upstream of or within inner ear morphogenesis IGI
IGI: Inferred from genetic interaction
9729491 MGI
acts upstream of mesenchymal cell proliferation IGI
IGI: Inferred from genetic interaction
11532916 MGI
acts upstream of or within middle ear morphogenesis IGI
IGI: Inferred from genetic interaction
9729491 MGI
acts upstream of or within positive regulation of mesenchymal cell proliferation IGI
IGI: Inferred from genetic interaction
11532916 MGI
acts upstream of or within positive regulation of smoothened signaling pathway IGI
IGI: Inferred from genetic interaction
11532916 MGI
acts upstream of or within positive regulation of stem cell proliferation IGI
IGI: Inferred from genetic interaction
11532916 MGI
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
12713735 MGI
acts upstream of smoothened signaling pathway IGI
IGI: Inferred from genetic interaction
11532916 MGI
acts upstream of stem cell proliferation IGI
IGI: Inferred from genetic interaction
11532916 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

paired mesoderm homeobox protein 2

  • PRX-2

  • homeo box of paired rule

  • homeobox protein S8

  • surface antigen, homeo box of paired rule

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11244 PRRX2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22743 Prrx2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29257 Prrx2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Prrx2 NCBI NCBI:51450