Sstr1 - somatostatin receptor 1 Gene

Also Known as SS1R; sst1; SS1-R; SRIF-2; SS-1-R; Smstr1; Smstr-1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20605

About Sstr1

Chromosome 12: 58,258,558-58,261,230 forward strand.GRCm39:CM001005.3

This gene has 2 transcripts (splice variants), 160 orthologues, 15 paralogues and is associated with 8 phenotypes. Biased expression in colon adult (RPKM 12.3), CNS E18 (RPKM 7.4) and 1 other tissues.

Summary

Enables Somatostatin Receptor activity. Acts upstream of or within cellular response to leukemia inhibitory factor; glutamate receptor signaling pathway; and neuropeptide signaling pathway. Located in plasma membrane. Is expressed in several structures, including brain; eye; genitourinary system; gut; and respiratory system. Orthologous to human SSTR1 (Somatostatin Receptor 1). [provided by Alliance of Genome Resources, Apr 2022]

Sstr1 Products (2)

mRNA Protein Name
NM_001411890.1 NP_001398819.1 somatostatin receptor type 1
NM_009216.3 NP_033242.1 somatostatin receptor type 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
17950729 MGI
enables somatostatin receptor activity IDA
IDA: Inferred from direct assay
7929134 MGI
enables somatostatin receptor activity IMP
IMP: Inferred from mutant phenotype
7929134 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within G protein-coupled receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
7929134 MGI
acts upstream of or within cellular response to leukemia inhibitory factor IEP
IEP: Inferred from expression pattern
20439489 MGI
acts upstream of or within glutamate receptor signaling pathway IDA
IDA: Inferred from direct assay
9166719 MGI
acts upstream of or within neuropeptide signaling pathway IDA
IDA: Inferred from direct assay
9166719 MGI
Cellular Component GO Annotation Evidence References Source
located in membrane IDA
IDA: Inferred from direct assay
7929134 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
9166719 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Sstr1 Protein Structure

7tmA_SSTR1

7tmA_SSTR1: cd15970 (58 - 333)

7tmA_SSTR1

7tmA_SSTR1: cd15970 (59 - 85)

7tmA_SSTR1

7tmA_SSTR1: cd15970 (92 - 118)

7tmA_SSTR1

7tmA_SSTR1: cd15970 (129 - 159)

7tmA_SSTR1

7tmA_SSTR1: cd15970 (171 - 193)

7tmA_SSTR1

7tmA_SSTR1: cd15970 (219 - 248)

7tmA_SSTR1

7tmA_SSTR1: cd15970 (263 - 293)

7tmA_SSTR1

7tmA_SSTR1: cd15970 (301 - 326)

  • 0
  • 100
  • 200
  • 300
  • 391 a.a.
Protein Preferred Names Protein Names

somatostatin receptor type 1

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-105172 TT-232 Agonist 98.72% Phase 2

Pre-clinical Phase

Bioactive Molecules (9)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P1932 Cortistatin-14 99.98% Unkown
HY-P1206 CH 275 Agonist 99.52% Unkown
HY-P1201 Cyclosomatostatin Antagonist 99.56% Unkown
HY-P4452 PRL 2915 Antagonist 99.92% Unkown
HY-P3618 Cortistatin-29 (reduced) 98.12% Unkown
HY-125382A L-797591 hydrochloride Agonist 99.81% Unkown
HY-P4469 PRL 3195 Antagonist / Unkown
HY-P2150 Cortistatin-29 (rat) / Unkown
HY-P1201A Cyclosomatostatin TFA Antagonist / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sstr1 NCBI NCBI:6751