SSTR1 - somatostatin receptor 1 Gene

Also Known as SS1R; SST1; SS1-R; SRIF-2; SS-1-R

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6751

About SSTR1

Cytogenetic location: 14q21.1 Genomic coordinates (GRCh38): 14:38,207,904-38,213,067 (from NCBI)

This gene has 1 transcript (splice variant), 160 orthologues and 17 paralogues. Biased expression in stomach (RPKM 11.3), duodenum (RPKM 7.3) and 9 other tissues.

Summary

Somatostatins are peptide Hormones that regulate diverse cellular functions such as neurotransmission, cell proliferation, and endocrine signaling as well as inhibiting the release of many Hormones and Other secretory proteins. Somatostatin has two active forms of 14 and 28 Amino acids. The biological effects of somatostatins are mediated by a family of G-protein coupled somatostatin receptors that are expressed in a tissue-specific manner. The protein encoded by this gene is a member of the superfamily of somatostatin receptors having seven transmembrane segments. Somatostatin receptors form homodimers and heterodimers with Other members of the superfamily as well as with Other G-protein coupled receptors and Receptor Tyrosine Kinases. This Somatostatin Receptor has greater affinity for somatostatin-14 than -28. [provided by RefSeq, Jul 2012]

SSTR1 Products (2)

mRNA	Protein	Name
XM_047431728.1	XP_047287684.1	somatostatin receptor type 1 isoform X1
NM_001049.3	NP_001040.1	somatostatin receptor type 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15247250	GOA
enables somatostatin receptor activity	IDA IDA: Inferred from direct assay	1346068	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SSTR1 Protein Structure

7tm_1

0
100
200
300
391 a.a.

Protein Preferred Names	Protein Names
somatostatin receptor type 1

SSTR1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SSTR1	P30872	SSTR5	Homo sapiens	P35346	FRET	15247250
Intra	SSTR1	P30872	SSTR5	Homo sapiens	P35346	Anti Tag CoIP	15247250
Intra	SSTR1	P30872	SSTR5	Homo sapiens	P35346	Confocal	15247250

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Intracranial Hypertension, Idiopathic	Pseudotumor Cerebri Benign Intracranial Hypertension Idiopathic Intracranial Hypertension Iih Benign Intracran. Hypt.
Pancreatic Cystadenoma	Cystadenoma Of Pancreas
Acromegaly	Gigantism Growth Hormone Excess Pituitary Giant Somatotroph Adenoma Growth Hormone-Secreting Pituitary Adenoma
Thyroid Carcinoma, Familial Medullary	Medullary Thyroid Carcinoma Familial Medullary Thyroid Carcinoma MTC Fmtc Mtc1 Thyroid Cancer, Medullary Medullary Thyroid Cancer Thyroid Carcinoma, Medullary Familial Mtc Thyroid Carcinoma Medullary Carcinoma, Thyroid, Medullary, Familial Medullary Carcinoma Of Thyroid Medullary Carcinoma With Amyloid Stroma, Unspecified Site Medullary Carcinoma With Amyloid Stroma Of Thyroid
Pituitary Adenoma	Pituitary Neoplasms Adenoma Of The Pituitary Gland Pituitary Adenomas Adenoma, Pituitary Pituitary Gland Adenoma
Thyroid Gland Cancer	Thyroid Gland Carcinoma Malignant Neoplasm Of Thyroid Gland Malignant Tumour Of Thyroid Gland Thyroid Neoplasm Thyroid Neoplasms Neoplasm Of Thyroid Gland Thyroid Gland Neoplasm Head And Neck Cancer, Thyroid Neoplasm Of The Thyroid Gland Cancer Of The Thyroid Primary Malignant Neoplasm Of Thyroglossal Duct Malignant Neoplasm Of Thyroglossal Duct Primary Malignant Neoplasm Of Thyroid Gland Thyroglossal Duct Cancer Toxic Goitre Malignant Tumour Cancerous Goitre
Gastrointestinal Neuroendocrine Tumor	Gastrointestinal Neuroendocrine Tumour Malignant Gastrointestinal Neuroendocrine Tumor Malignant Gastrointestinal Neuroendocrine Tumour Digestive System Neuroendocrine Neoplasm Digestive System Neuroendocrine Tumor
Acth-Secreting Pituitary Adenoma	Acth-Producing Pituitary Adenoma Corticotroph Adenoma Corticotropinoma Pituitary-Dependent Cushing'S Disease Adrenal Gland Hyperfunction Cushing Syndrome
Meningioma, Familial	Meningioma Familial Meningioma Meningioma, Familial, Susceptibility To Meningeal Neoplasm Meningeal Neoplasms Meningiomas Meningioma, Nf2-Related, Somatic Meningioma, Sis-Related Meningothelial Cell Tumor Neoplasm Of The Meninges Primary Meningeal Tumor Familial Multiple Meningioma MNGMA Meningioma, Benign, No Icd-O Subtype Intracranial Meningioma Meningothelial Cell Neoplasm Supratentorial Meningioma Primary Neoplasm Of Spinal Meninges Benign Intracranial Meningioma Benign Meningioma Meningeal Tumours Meningeal Sarcoma Of Unspecified Site Meningothelial Sarcoma Of Unspecified Site
Growth Hormone Secreting Pituitary Adenoma	Somatotroph Adenoma Growth Hormone-Secreting Pituitary Adenoma Growth Hormone Producing Adenoma Of The Pituitary Growth Hormone Secreting Adenoma Of Pituitary
Serotonin Syndrome	Serotonergic Syndrome Serotonin Storm Serotonin Toxicity Serotonin Toxidrome Malignant Carcinoid Syndrome
Polycystic Liver Disease	Autosomal Dominant Polycystic Liver Disease Isolated Polycystic Liver Disease Pcld Congenital Cystic Liver Disease Congenital Hepatic Cyst Fibrocystic Liver Disease Isolated Autosomal Dominant Polycystic Liver Disease Adpcld Liver Disease, Polycystic Multiple Cysts Of Liver Pld - [Polycystic Liver Disease] Polycystic Liver Disorder Polycystic Liver Congenital Polycystic Disease Of Liver Congenital Polycystic Liver Disease
Hormone Producing Pituitary Cancer	Growth Hormone Producing Pituitary Tumor Pituitary Tumors, Hormone Producing Somatotropinoma Growth Hormone-Producing Pituitary Gland Neoplasm
Prolactinoma	Prolactin-Producing Pituitary Gland Adenoma Prolactin-Secreting Pituitary Adenoma Forbes-Albright Syndrome Lactotroph Adenoma Prl-Secreting Pituitary Adenoma Prloma Pituitary Lactotrophic Adenoma Familial Prolactinoma Pituitary Adenoma, Prolactin-Secreting Prolactinoma Of Pituitary Gland PSPA
Pheochromocytoma	Pheochromocytoma, Susceptibility To Phaeochromocytoma Adrenal Gland Chromaffin Paraganglioma Adrenal Gland Chromaffinoma Adrenal Gland Paraganglioma Adrenal Gland Pheochromocytoma Chromaffin Paraganglioma Of The Adrenal Gland Intraadrenal Paraganglioma PCC Chromaffin Cell Tumor Medullary Chromaffinoma Medullary Paraganglioma Pheochromoblastoma Pheochromocytomas Chromaffin Cell Neoplasm Pheochromocytoma, Malignant
Microcystic Meningioma
Functioning Pituitary Adenoma	Secretory Adenoma Of The Pituitary Gland Endocrine Active Pituitary Adenoma Secreting Pituitary Adenoma Pituitary Adenoma, Functioning
Pituitary Gland Disease	Pituitary Diseases Pituitary Dysfunction Pituitary Disease Pituitary Deficiency Pituitary Disorders
Hyperpituitarism
Insulinoma	Islet Cell Adenoma Insulin-Producing Tumor Of Islet Cells Adenoma Islet Cell Islet Cell Tumor Experimental Organism Islet Cell Adenoma Neoplasm

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-105172	TT-232	Agonist	98.72%	Phase 2

Pre-clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P1932	Cortistatin-14		99.98%	Unkown
HY-P1206	CH 275	Agonist	99.52%	Unkown
HY-P1201	Cyclosomatostatin	Antagonist	99.56%	Unkown
HY-P4452	PRL 2915	Antagonist	99.92%	Unkown
HY-P3618	Cortistatin-29 (reduced)		98.12%	Unkown
HY-125382A	L-797591 hydrochloride	Agonist	99.81%	Unkown
HY-P4469	PRL 3195	Antagonist	/	Unkown
HY-P2150	Cortistatin-29 (rat)		/	Unkown
HY-P1201A	Cyclosomatostatin TFA	Antagonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	SSTR1	VGNC	VGNC:35325
Macaca mulatta	SSTR1	VGNC	VGNC:99246
Canis familiaris	SSTR1	VGNC	VGNC:46843
Mus musculus	SSTR1	MGD	MGI:98327
Felis catus	SSTR1	VGNC	VGNC:80832
Rattus norvegicus	SSTR1	RGD	RGD:3762
Others	SSTR1	NCBI