Snca - synuclein, alpha Gene

Also Known as NACP; alphaSYN; alpha-Syn

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20617

About Snca

Chromosome 6: 60,708,559-60,806,839 reverse strand.GRCm39:CM000999.3

This gene has 4 transcripts (splice variants), 189 orthologues, 2 paralogues and is associated with 28 phenotypes. Biased expression in liver E14 (RPKM 144.4), liver E14.5 (RPKM 119.8) and 1 other tissues.

Summary

Enables arachidonic acid binding activity; histone binding activity; and identical protein binding activity. Involved in several processes, including positive regulation of peptidyl-serine phosphorylation; protein-containing complex assembly; and synaptic vesicle endocytosis. Acts upstream of or within several processes, including chemical synaptic transmission; modulation of chemical synaptic transmission; and regulation of amine transport. Located in several cellular components, including inclusion body; neuronal cell body; and synaptic vesicle membrane. Is expressed in several structures, including brain; genitourinary system; liver; retina; and spleen. Used to study Parkinson's disease 1 and Parkinson's disease 4. Human ortholog(s) of this gene implicated in Alzheimer's disease; Lewy body dementia; Parkinson's disease; Parkinson's disease 1; and Parkinson's disease 4. Orthologous to human SNCA (synuclein alpha). [provided by Alliance of Genome Resources, Apr 2022]

Snca Products (2)

mRNA Protein Name
NM_001042451.2 NP_001035916.1 alpha-synuclein
NM_009221.2 NP_033247.1 alpha-synuclein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables arachidonate binding IDA
IDA: Inferred from direct assay
16734431 MGI
enables histone binding IDA
IDA: Inferred from direct assay
16959795 MGI
enables identical protein binding IDA
IDA: Inferred from direct assay
10978144 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
17296554 MGI
Biological Process GO Annotation Evidence References Source
involved in SNARE complex assembly IDA
IDA: Inferred from direct assay
25246573 MGI
acts upstream of or within adult locomotory behavior IGI
IGI: Inferred from genetic interaction
18333965 MGI
acts upstream of or within cellular response to oxidative stress IMP
IMP: Inferred from mutant phenotype
16298531 MGI
acts upstream of or within chemical synaptic transmission IGI
IGI: Inferred from genetic interaction
20974939 MGI
acts upstream of or within dopamine biosynthetic process IMP
IMP: Inferred from mutant phenotype
10707987 MGI
acts upstream of or within dopamine metabolic process IGI
IGI: Inferred from genetic interaction
15465911 MGI
acts upstream of or within excitatory postsynaptic potential IMP
IMP: Inferred from mutant phenotype
17610578 MGI
acts upstream of or within fatty acid metabolic process IMP
IMP: Inferred from mutant phenotype
14507911 MGI
acts upstream of or within long-term synaptic potentiation IMP
IMP: Inferred from mutant phenotype
17689254 MGI
acts upstream of or within membrane organization IMP
IMP: Inferred from mutant phenotype
14507911 MGI
acts upstream of or within microglial cell activation IMP
IMP: Inferred from mutant phenotype
17035541 MGI
acts upstream of or within mitochondrial ATP synthesis coupled electron transport IMP
IMP: Inferred from mutant phenotype
16260631 MGI
acts upstream of or within mitochondrial membrane organization IMP
IMP: Inferred from mutant phenotype
16260631 MGI
acts upstream of or within negative regulation of neuron apoptotic process IGI
IGI: Inferred from genetic interaction
16269331 MGI
acts upstream of neuron apoptotic process IGI
IGI: Inferred from genetic interaction
16269331 MGI
acts upstream of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
15380020 MGI
acts upstream of neurotransmitter secretion IDA
IDA: Inferred from direct assay
15510220 MGI
acts upstream of or within neutral lipid metabolic process IMP
IMP: Inferred from mutant phenotype
17250686 MGI
acts upstream of or within phospholipid metabolic process IMP
IMP: Inferred from mutant phenotype
15938614 MGI
acts upstream of or within positive regulation of neurotransmitter secretion IDA
IDA: Inferred from direct assay
15510220 MGI
involved in positive regulation of peptidyl-serine phosphorylation IMP
IMP: Inferred from mutant phenotype
21127069 MGI
acts upstream of or within positive regulation of synaptic transmission IMP
IMP: Inferred from mutant phenotype
15579163 MGI
involved in protein complex oligomerization IDA
IDA: Inferred from direct assay
25246573 MGI
acts upstream of or within regulation of acyl-CoA biosynthetic process IDA
IDA: Inferred from direct assay
16734431 MGI
acts upstream of or within regulation of acyl-CoA biosynthetic process IMP
IMP: Inferred from mutant phenotype
16636270 MGI
acts upstream of or within regulation of dopamine secretion IGI
IGI: Inferred from genetic interaction
18333965 MGI
acts upstream of or within regulation of glutamate secretion IMP
IMP: Inferred from mutant phenotype
17689254 MGI
acts upstream of or within regulation of locomotion IMP
IMP: Inferred from mutant phenotype
10707987 MGI
acts upstream of or within regulation of long-term neuronal synaptic plasticity IMP
IMP: Inferred from mutant phenotype
15510220 MGI
acts upstream of or within regulation of macrophage activation IMP
IMP: Inferred from mutant phenotype
17035541 MGI
NOT acts upstream of or within regulation of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
15380020 MGI
acts upstream of or within regulation of neuronal synaptic plasticity IMP
IMP: Inferred from mutant phenotype
17610578 MGI
acts upstream of or within regulation of neurotransmitter secretion IGI
IGI: Inferred from genetic interaction
18333965 MGI
acts upstream of or within regulation of neurotransmitter secretion IMP
IMP: Inferred from mutant phenotype
10707987 MGI
involved in regulation of reactive oxygen species metabolic process IMP
IMP: Inferred from mutant phenotype
25043722 MGI
acts upstream of or within response to xenobiotic stimulus IMP
IMP: Inferred from mutant phenotype
10707987 MGI
acts upstream of or within synapse organization IGI
IGI: Inferred from genetic interaction
20974939 MGI
acts upstream of or within synaptic transmission, dopaminergic IMP
IMP: Inferred from mutant phenotype
10707987 MGI
involved in synaptic vesicle endocytosis IDA
IDA: Inferred from direct assay
25009269 MGI
involved in synaptic vesicle endocytosis IMP
IMP: Inferred from mutant phenotype
18980610 MGI
acts upstream of or within synaptic vesicle transport IMP
IMP: Inferred from mutant phenotype
12388586 MGI
Cellular Component GO Annotation Evidence References Source
located in axon terminus IDA
IDA: Inferred from direct assay
17296554 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
17475220 MGI
located in cytoskeleton IDA
IDA: Inferred from direct assay
17077307 MGI
located in cytosol IDA
IDA: Inferred from direct assay
18980610 MGI
located in inclusion body IDA
IDA: Inferred from direct assay
17222866 MGI
located in neuronal cell body IMP
IMP: Inferred from mutant phenotype
26203154 MGI
located in nucleus IDA
IDA: Inferred from direct assay
16959795 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
17475220 MGI
located in synapse IDA
IDA: Inferred from direct assay
10964942 MGI
is active in synaptic vesicle membrane IDA
IDA: Inferred from direct assay
28052246 MGI
is active in synaptic vesicle membrane IEP
IEP: Inferred from expression pattern
28052246 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Snca Protein Structure

Synuclein

Synuclein: pfam01387 (0 - 130)

  • 0
  • 100
  • 140 a.a.
Protein Preferred Names Protein Names

alpha-synuclein

  • non-A beta component of AD amyloid

  • non-A4 component of amyloid

Snca Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Snca O55042 Sod1 Mus musculus P08228
Anti Bait CoIP
26643113
Intra
Snca O55042 Rab8a Mus musculus P55258
Anti Bait CoIP
24983211
Intra
Snca O55042 Slc6a3 Mus musculus Q61327
IF
22163275
Intra
Snca O55042 Slc6a3 Mus musculus Q61327
Anti Bait CoIP
22163275
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant Snca Proteins

Cat. No. Product Name Accession Purity
HY-P70660 SNCA Protein, Mouse O55042-1 (M1-A140) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive MoleculesInhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P990898 Amlenetug 99.85% Phase 3

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-135902A Synucleozid hydrochloride Inhibitor 98.23% Unkown
HY-135902 Synucleozid Inhibitor / Unkown
HY-125984 Syn-516 Inhibitor / Unkown
HY-401209 Synucleozid-2.0 Inhibitor 98.01% Unkown
HY-RS13482 SNCA Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13483 Snca Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13484 Snca Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Bioactive MoleculesInhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990922 Indenebart 99.53% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Snca NCBI NCBI:6622