Plk2 - polo like kinase 2 Gene

Also Known as Snk

Species: Mus musculus

Gene Type: protein coding

Gene ID: 20620

About Plk2

Chromosome 13: 110,531,580-110,537,378 forward strand.GRCm39:CM001006.3

This gene has 5 transcripts (splice variants), 221 orthologues, 4 paralogues and is associated with 11 phenotypes. Broad expression in CNS E18 (RPKM 28.3), cortex adult (RPKM 24.4) and 22 other tissues.

Summary

Enables protein serine/threonine kinase activity. Involved in several processes, including negative regulation of apoptotic process in bone marrow cell; negative regulation of cellular senescence; and positive regulation of cell migration involved in sprouting angiogenesis. Acts upstream of or within mitotic cell cycle and negative regulation of apoptotic process. Located in chromatin. Is expressed in several structures, including alimentary system; hindlimb interdigital region; integumental system; nervous system; and skeleton. Orthologous to human PLK2 (polo like kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Plk2 Products (1)

mRNA	Protein	Name
NM_152804.2	NP_690017.2	serine/threonine-protein kinase PLK2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	12897130	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in memory	IMP IMP: Inferred from mutant phenotype	21382555	MGI
acts upstream of or within mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	12972611	MGI
involved in mitotic spindle organization	IMP IMP: Inferred from mutant phenotype	12897130	MGI
involved in negative regulation of angiogenesis	IMP IMP: Inferred from mutant phenotype	26934179	MGI
acts upstream of or within negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	12897130	MGI
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	12897130	MGI
involved in negative regulation of apoptotic process in bone marrow cell	IMP IMP: Inferred from mutant phenotype	27908889	MGI
involved in negative regulation of cellular senescence	IMP IMP: Inferred from mutant phenotype	27908889	MGI
involved in positive regulation of cell migration involved in sprouting angiogenesis	IMP IMP: Inferred from mutant phenotype	27908889	MGI
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	12897130	MGI
involved in regulation of synaptic plasticity	IMP IMP: Inferred from mutant phenotype	21382555	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in chromatin	IDA IDA: Inferred from direct assay	22854038	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Plk2 Protein Structure

STKc_PLK2

POLO_box_1

POLO_box_2

0
200
400
600
682 a.a.

Protein Preferred Names	Protein Names
serine/threonine-protein kinase PLK2	PLK-2 serine/threonine-protein kinase SNK serum-inducible kinase

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12137A	Volasertib trihydrochloride	Inhibitor	99.12%	Yes

Clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Phase
HY-12137	Volasertib	Inhibitor	99.97%	Phase 3
HY-12037	Rigosertib sodium	Inhibitor	99.57%	Phase 3
HY-147298	Plogosertib	Inhibitor	98.59%	Phase 2
HY-15160	TAK-960	Inhibitor	99.75%	Phase 1

Pre-clinical Phase

Bioactive Molecules (14)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-50698	BI 2536	Inhibitor	99.95%	Unkown
HY-12037A	Rigosertib	Inhibitor	99.01%	Unkown
HY-100789	ON1231320	Inhibitor	99.90%	Unkown
HY-12134	Poloxin	Inhibitor	98.05%	Unkown
HY-108597	TC-S 7005	Inhibitor	99.68%	Unkown
HY-180896	8012–3246	Inhibitor	99.72%	Unkown
HY-173212	PLK1-IN-13	Inhibitor	/	Unkown
HY-149100	PLK1-IN-6	Inhibitor	/	Unkown
HY-15160B	TAK-960 dihydrochloride	Inhibitor	99.15%	Unkown
HY-172364	PLK1-IN-12	Inhibitor	/	Unkown
HY-115589	YLT-11	Inhibitor	/	Unkown
HY-181030	BDE30671203	Inhibitor	/	Unkown
HY-181051	PLK1-IN-16	Inhibitor	/	Unkown
HY-15160A	TAK-960 hydrochloride	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Plk2	NCBI	NCBI:10769