Spop - speckle-type BTB/POZ protein Gene

Also Known as TEF2; Pcif1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20747

Summary

Enables RNA polymerase II-specific DNA-binding transcription factor binding activity. Acts upstream of or within several processes, including glucose homeostasis; positive regulation of apoptotic process; and regulation of transcription, DNA-templated. Located in nuclear speck. Is expressed in lung; metanephros; and pancreas. Orthologous to human SPOP (speckle type BTB/POZ protein). [provided by Alliance of Genome Resources, Apr 2022]

Spop Products (2)

mRNA Protein Name
NM_001359107.1 NP_001346036.1 speckle-type POZ protein
NM_025287.2 NP_079563.2 speckle-type POZ protein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
IPI: Inferred from physical interaction
19684112 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
15121856 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within glucose homeostasis IGI
IGI: Inferred from genetic interaction
20679732 MGI
acts upstream of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IGI
IGI: Inferred from genetic interaction
20811152 MGI
acts upstream of or within negative regulation of DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
15121856 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
15121856 MGI
acts upstream of or within positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IGI
IGI: Inferred from genetic interaction
20811152 MGI
acts upstream of or within positive regulation of type B pancreatic cell apoptotic process IGI
IGI: Inferred from genetic interaction
20679732 MGI
acts upstream of or within proteasome-mediated ubiquitin-dependent protein catabolic process IGI
IGI: Inferred from genetic interaction
20811152 MGI
acts upstream of type B pancreatic cell apoptotic process IGI
IGI: Inferred from genetic interaction
20679732 MGI
acts upstream of or within ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
19684112 MGI
Cellular Component GO Annotation Evidence References Source
located in nuclear speck IDA
IDA: Inferred from direct assay
15121856 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

speckle-type POZ protein

  • HIB homolog 1

  • PDX-1 C-terminal-interacting factor 1

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-136938 NEO2734 Inhibitor 99.63% Phase 1

Pre-clinical Phase

Bioactive Molecules (11)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-122615 SPOP-IN-6b 99.56% Unkown
HY-122615B SPOP-IN-6b dihydrochloride Inhibitor 99.70% Unkown
HY-156382 SPOP-IN-1 Inhibitor 99.71% Unkown
HY-161251 SPOP-IN-2 91.00% Unkown
HY-175247 DDO-4033 99.11% Unkown
HY-122615A SPOP-IN-6b hydrochloride Inhibitor / Unkown
HY-176035 MS479 Degrader / Unkown
HY-RS13700 SPOP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-176038 MS1262-C3-amide-C10-amine / Unkown
HY-RS16789 Spop Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23229 Spop Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Spop NCBI NCBI:8405