Stim1 - stromal interaction molecule 1 Gene

Also Known as SIM

Species: Mus musculus

Gene Type: protein coding

Gene ID: 20866

Summary

Enables identical protein binding activity. Acts upstream of or within myotube differentiation and store-operated calcium entry. Located in endoplasmic reticulum. Part of protein-containing complex. Is expressed in several structures, including alimentary system; central nervous system; gonad; hemolymphoid system gland; and musculature. Human ortholog(s) of this gene implicated in Stormorken syndrome; immunodeficiency 10; and tubular aggregate myopathy 1. Orthologous to human STIM1 (stromal interaction molecule 1). [provided by Alliance of Genome Resources, Apr 2022]

Stim1 Products (4)

mRNA	Protein	Name
NM_001374058.1	NP_001360987.1	stromal interaction molecule 1 isoform 2 precursor
NM_001374060.1	NP_001360989.1	stromal interaction molecule 1 isoform 3 precursor
NM_001400557.1	NP_001387486.1	stromal interaction molecule 1 isoform 4 precursor
NM_009287.5	NP_033313.2	stromal interaction molecule 1 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables calcium channel regulator activity	IDA IDA: Inferred from direct assay	18452988	MGI
enables calcium channel regulator activity	IMP IMP: Inferred from mutant phenotype	31664108	MGI
enables channel activator activity	IDA IDA: Inferred from direct assay	18452988	MGI
enables channel activator activity	IMP IMP: Inferred from mutant phenotype	31664108	MGI
enables identical protein binding	IPI IPI: Inferred from physical interaction	20037597	MGI
enables ion channel regulator activity involved in G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	18452988	MGI
enables ion channel regulator activity involved in G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	31664108	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	11463338	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within establishment of localization in cell	IMP IMP: Inferred from mutant phenotype	17647013	MGI
involved in ion channel modulating, G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	18452988	MGI
involved in ion channel modulating, G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	30131394	MGI
involved in ligand-gated ion channel signaling pathway	IDA IDA: Inferred from direct assay	18452988	MGI
involved in ligand-gated ion channel signaling pathway	IMP IMP: Inferred from mutant phenotype	30131394	MGI
acts upstream of or within monoatomic cation transport	IMP IMP: Inferred from mutant phenotype	17647013	MGI
acts upstream of or within myotube differentiation	IMP IMP: Inferred from mutant phenotype	23206701	MGI
involved in phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway	IDA IDA: Inferred from direct assay	18452988	MGI
involved in phospholipase C-activating G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	30131394	MGI
involved in positive regulation of insulin secretion	IDA IDA: Inferred from direct assay	18452988	MGI
involved in positive regulation of insulin secretion	IMP IMP: Inferred from mutant phenotype	30131394	MGI
acts upstream of or within store-operated calcium entry	IGI IGI: Inferred from genetic interaction	17343823	MGI
acts upstream of or within store-operated calcium entry	IMP IMP: Inferred from mutant phenotype	31637311	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	23840669	MGI
is active in plasma membrane	IDA IDA: Inferred from direct assay	18452988	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
stromal interaction molecule 1

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-101942	Zegocractin	Inhibitor	99.96%	Phase 2

Pre-clinical Phase

Bioactive Molecules (17)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-100001	SKF-96365 (hydrochloride)		99.93%	Unkown
HY-100932	ML-9	Inhibitor	99.86%	Unkown
HY-19408	Pyr10	Inhibitor	99.95%	Unkown
HY-N1353	Rhamnocitrin	Inhibitor	99.67%	Unkown
HY-113618B	RO2959 monohydrochloride	Inhibitor	98.03%	Unkown
HY-W099504	1-Heptanol		99.92%	Unkown
HY-125942	SKF-96365		99.97%	Unkown
HY-RS13913	STIM1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-158990	GE1111		95.73%	Unkown
HY-113618A	RO2959 hydrochloride	Inhibitor	99.12%	Unkown
HY-100932A	ML-9 Free Base	Inhibitor	/	Unkown
HY-103071	GSK-5503A	Inhibitor	/	Unkown
HY-181953	STIM1-TFR1-IN-1	Inhibitor	/	Unkown
HY-W099504S	1-Heptanol-d15		99.05%	Unkown
HY-W099504S1	1-Heptanol-d7		/	Unkown
HY-RS16865	Stim1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23306	Stim1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Stim1	NCBI	NCBI:6786