Plk4 - polo like kinase 4 Gene

Also Known as Sak; Stk18; 1700028H20

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20873

About Plk4

Chromosome 3: 40,754,454-40,771,318 forward strand.GRCm39:CM000996.3

This gene has 10 transcripts (splice variants), 210 orthologues, 4 paralogues and is associated with 12 phenotypes. Broad expression in CNS E11.5 (RPKM 11.4), liver E14 (RPKM 9.6) and 16 other tissues.

Summary

This gene encodes a member of the polo family of serine/threonine protein kinases. The protein localizes to the nucleolus during G2, to centrosomes during G2/M, and to the cleavage furrow during cytokinesis. It is required for progression through Mitosis, cell survival, and embryonic development. The mouse genome contains a pseudogene similar to this gene. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

Plk4 Products (4)

mRNA Protein Name
NM_173169.3 NP_775261.2 serine/threonine-protein kinase PLK4 isoform 2
NM_001410621.1 NP_001397550.1 serine/threonine-protein kinase PLK4 isoform 3
NM_001410622.1 NP_001397551.1 serine/threonine-protein kinase PLK4 isoform 4
NM_011495.3 NP_035625.2 serine/threonine-protein kinase PLK4 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
17174311 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
17174311 MGI
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
17891141 MGI
Biological Process GO Annotation Evidence References Source
involved in centriole replication IMP
IMP: Inferred from mutant phenotype
24240477 MGI
involved in de novo centriole assembly involved in multi-ciliated epithelial cell differentiation IMP
IMP: Inferred from mutant phenotype
24240477 MGI
involved in trophoblast giant cell differentiation IMP
IMP: Inferred from mutant phenotype
17891141 MGI
Cellular Component GO Annotation Evidence References Source
located in XY body IDA
IDA: Inferred from direct assay
22854038 MGI
located in deuterosome IDA
IDA: Inferred from direct assay
24240477 MGI
located in nucleolus IDA
IDA: Inferred from direct assay
17891141 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Plk4 Protein Structure

STKc_PLK4

STKc_PLK4: cd14186 (9 - 264)

POLO_box_Plk4_1

POLO_box_Plk4_1: cd13114 (547 - 658)

Plk4_PB2

Plk4_PB2: pfam18409 (659 - 767)

POLO_box_Plk4_3

POLO_box_Plk4_3: cd13116 (838 - 917)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 925 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase PLK4

  • serine/threonine kinase 18

  • serine/threonine-protein kinase 18

  • serine/threonine-protein kinase Sak

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Phase
HY-149324 SP27 Degrader 98.87% Phase 4
HY-12300 Ocifisertib Inhibitor 99.78% Phase 2
HY-12300B Ocifisertib fumarate Inhibitor 98.69% Phase 2
HY-172737 RP-1664 Inhibitor 98.77% Phase 1

Pre-clinical Phase

Bioactive Molecules (12)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-18682 Centrinone Inhibitor 98.28% Unkown
HY-100789 ON1231320 Inhibitor 99.90% Unkown
HY-18683 Centrinone-B Inhibitor 98.65% Unkown
HY-128493 PLK4-IN-4 Inhibitor 99.89% Unkown
HY-132135 (1E)-CFI-400437 dihydrochloride Inhibitor 98.08% Unkown
HY-149912 CZS-241 Inhibitor / Unkown
HY-12300A Ocifisertib hydrochloride Inhibitor 98.29% Unkown
HY-176734 CZL-S092 Inhibitor / Unkown
HY-115589 YLT-11 Inhibitor / Unkown
HY-180111 PLK4-IN-7 Inhibitor / Unkown
HY-134775A PLK4-IN-3 Inhibitor / Unkown
HY-179149 PLK4-IN-6 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Plk4 NCBI NCBI:10733