Tfe3 - transcription factor E3 Gene

Also Known as Tcfe3; Tfe-3; mTFE3; bHLHe33; F830016E06Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 209446

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein heterodimerization activity. Involved in several processes, including negative regulation of cold-induced thermogenesis; positive regulation of brown fat cell differentiation; and positive regulation of transcription by RNA polymerase II. Acts upstream of or within positive regulation of transcription, DNA-templated and regulation of osteoclast differentiation. Located in cytosol and nucleus. Is expressed in several structures, including adipose tissue; branchial arch; early conceptus; genitourinary system; and gut. Human ortholog(s) of this gene implicated in renal cell carcinoma. Orthologous to human TFE3 (transcription factor binding to IGHM enhancer 3). [provided by Alliance of Genome Resources, Apr 2022]

Tfe3 Products (6)

mRNA Protein Name
NM_001105196.1 NP_001098666.1 transcription factor E3 isoform b
NM_001105197.1 NP_001098667.1 transcription factor E3 isoform c
NM_001271489.1 NP_001258418.1 transcription factor E3 isoform c
NM_001271490.1 NP_001258419.1 transcription factor E3 isoform c
NM_001271491.1 NP_001258420.1 transcription factor E3 isoform d
NM_172472.3 NP_766060.2 transcription factor E3 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
15994295 MGI
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
16936731 MGI
enables E-box binding IDA
IDA: Inferred from direct assay
20713358 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
20713358 MGI
enables protein heterodimerization activity IPI
IPI: Inferred from physical interaction
16936731 MGI
enables transcription cis-regulatory region binding IDA
IDA: Inferred from direct assay
16936731 MGI
Biological Process GO Annotation Evidence References Source
involved in humoral immune response IMP
IMP: Inferred from mutant phenotype
16936731 MGI
involved in negative regulation of cold-induced thermogenesis IMP
IMP: Inferred from mutant phenotype
23885019 MGI
acts upstream of or within positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
15994295 MGI
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
27913603 MGI
involved in positive regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
29146937 MGI
involved in positive regulation of brown fat cell differentiation IMP
IMP: Inferred from mutant phenotype
27913603 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
16936731 MGI
acts upstream of or within regulation of osteoclast differentiation IGI
IGI: Inferred from genetic interaction
11930005 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IMP
IMP: Inferred from mutant phenotype
21209915 MGI
located in cytosol IDA
IDA: Inferred from direct assay
27913603 MGI
located in nucleus IDA
IDA: Inferred from direct assay
21209915 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

transcription factor E3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14419 TFE3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174536 Human TFE3 mRNA / Unkown
HY-RS19388 Tfe3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25880 Tfe3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tfe3 NCBI NCBI:7030