Satb2 - special AT-rich sequence binding protein 2 Gene

Also Known as BAP002; mKIAA1034

Species: Mus musculus

Gene Type: protein coding

Gene ID: 212712

Summary

Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and chromatin binding activity. Acts upstream of or within several processes, including generation of neurons; regulation of transcription by RNA polymerase II; and skeletal system development. Located in nucleus. Part of histone deacetylase complex and transcription regulator complex. Is expressed in several structures, including 1st branchial arch; cerebral cortex; facial prominence; genitourinary system; and limb. Used to study isolated cleft palate. Human ortholog(s) of this gene implicated in SATB2-associated syndrome. Orthologous to human SATB2 (SATB homeobox 2). [provided by Alliance of Genome Resources, Apr 2022]

Satb2 Products (3)

mRNA	Protein	Name
NM_001358580.1	NP_001345509.1	DNA-binding protein SATB2
NM_001358581.1	NP_001345510.1	DNA-binding protein SATB2
NM_139146.2	NP_631885.1	DNA-binding protein SATB2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	15733084	MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	16751105	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	16751105	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	16751105	MGI
enables sequence-specific DNA binding	IGI IGI: Inferred from genetic interaction	16751105	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within cartilage development	IMP IMP: Inferred from mutant phenotype	16751105	MGI
acts upstream of or within chromatin remodeling	IDA IDA: Inferred from direct assay	18255031	MGI
acts upstream of or within embryonic pattern specification	IMP IMP: Inferred from mutant phenotype	16751105	MGI
acts upstream of or within embryonic skeletal system morphogenesis	IMP IMP: Inferred from mutant phenotype	16751105	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	16751105	MGI
acts upstream of or within neuron migration	IMP IMP: Inferred from mutant phenotype	18255031	MGI
acts upstream of or within osteoblast development	IGI IGI: Inferred from genetic interaction	16751105	MGI
acts upstream of or within osteoblast development	IMP IMP: Inferred from mutant phenotype	16751105	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16751105	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	16751105	MGI
acts upstream of or within regulation of gene expression	IMP IMP: Inferred from mutant phenotype	18255031	MGI
acts upstream of or within roof of mouth development	IMP IMP: Inferred from mutant phenotype	16751105	MGI

Cellular Component GO Annotation	Evidence	References	Source
part of histone deacetylase complex	IDA IDA: Inferred from direct assay	18255031	MGI
located in nucleus	IDA IDA: Inferred from direct assay	15733084	MGI
part of transcription regulator complex	IDA IDA: Inferred from direct assay	16751105	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
DNA-binding protein SATB2	KIAA1034-like DNA binding protein two cut domains-containing homeodomain protein

Satb2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Satb2	Q8VI24	Ski	Mus musculus	Q60698	Anti Bait CoIP	22334647
Intra	Satb2	Q8VI24	Hdac1	Mus musculus	O09106	Anti Bait CoIP	22334647
Intra	Satb2	Q8VI24	Hdac1	Mus musculus	O09106	Anti Bait CoIP	30726206
Intra	Satb2	Q8VI24	Cux1	Mus musculus	P53564	Anti Bait CoIP	30726206
Intra	Satb2	Q8VI24	Mta2	Mus musculus	Q9R190	Anti Bait CoIP	22334647
Intra	Satb2	Q8VI24	Mta2	Mus musculus	Q9R190	Anti Bait CoIP	30726206

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12458	SATB2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Satb2	NCBI	NCBI:23314