Mta2 - metastasis-associated gene family, member 2 Gene

Also Known as mmta2; Mta1l1; Mata1l1

Species: Mus musculus

Gene Type: protein coding

Gene ID: 23942

Summary

Enables histone deacetylase activity and transcription coregulator activity. Involved in negative regulation of transcription, DNA-templated. Acts upstream of or within DNA methylation; negative regulation of transcription by RNA polymerase II; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Part of NuRD complex. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; limb; and retina. Used to study systemic lupus erythematosus. Orthologous to human MTA2 (metastasis associated 1 family member 2). [provided by Alliance of Genome Resources, Apr 2022]

Mta2 Products (3)

mRNA	Protein	Name
NM_001412946.1	NP_001399875.1	metastasis-associated protein MTA2 isoform 2
NM_001412948.1	NP_001399877.1	metastasis-associated protein MTA2 isoform 2
NM_011842.4	NP_035972.3	metastasis-associated protein MTA2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables histone deacetylase activity	IDA IDA: Inferred from direct assay	10444591	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	11836251	MGI
enables transcription coregulator activity	IDA IDA: Inferred from direct assay	20636338	MGI

Biological Process GO Annotation	Evidence	Verweise	Source
acts upstream of or within genomic imprinting	IMP IMP: Inferred from mutant phenotype	20720167	MGI
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	20636338	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	11749719	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	11749719	MGI

Cellular Component GO Annotation	Evidence	Verweise	Source
part of NuRD complex	IDA IDA: Inferred from direct assay	14645126	MGI
part of NuRD complex	IPI IPI: Inferred from physical interaction	16462733	MGI
part of histone deacetylase complex	IDA IDA: Inferred from direct assay	10444591	MGI
located in nucleus	IDA IDA: Inferred from direct assay	11749719	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
metastasis-associated protein MTA2	metastais-associated gene family, member 2 metastasis-associated 1-like 1 metastasis-associated protein 2

Mta2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	Mta2	Q9R190	Pou5f1	Mus musculus	P20263	Anti Bait CoIP	20362541
Intra	Mta2	Q9R190	Sall4	Mus musculus	Q8BX22	Anti Bait CoIP	20362541
Intra	Mta2	Q9R190	Esrrb	Mus musculus	Q61539	Anti Bait CoIP	20362541
Intra	Mta2	Q9R190	Hdac1	Mus musculus	O09106	Anti Bait CoIP	20404188
Intra	Mta2	Q9R190	Hdac1	Mus musculus	O09106	Anti Bait CoIP	24240174
Intra	Mta2	Q9R190	Hdac1	Mus musculus	O09106	Anti Bait CoIP	19424149
Intra	Mta2	Q9R190	Hdac2	Mus musculus	P70288	Anti Bait CoIP	24240174
Intra	Mta2	Q9R190	Hdac2	Mus musculus	P70288	Anti Bait CoIP	19424149
Intra	Mta2	Q9R190	Hdac2	Mus musculus	P70288	Anti Bait CoIP	20404188

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS08747	MTA2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20776	Mta2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27290	Mta2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Mta2	NCBI	NCBI:9219