Tacc3 - transforming, acidic coiled-coil containing protein 3 Gene

Also Known as Aint; Eric1

Species: Mus musculus

Gene Type: protein coding

Gene ID: 21335

Summary

Enables protein domain specific binding activity. Acts upstream of or within several processes, including astral microtubule organization; cytoplasmic sequestering of transcription factor; and nervous system development. Located in centrosome and cytoplasm. Is expressed in several structures, including alimentary system; brain; early embryo; genitourinary system; and sensory organ. Orthologous to human TACC3 (transforming acidic coiled-coil containing protein 3). [provided by Alliance of Genome Resources, Apr 2022]

Tacc3 Products (12)

mRNA	Protein	Name
NM_001040435.4	NP_001035525.1	transforming acidic coiled-coil-containing protein 3 isoform 2
NM_001310541.2	NP_001297470.1	transforming acidic coiled-coil-containing protein 3 isoform 1
NM_001405350.1	NP_001392279.1	transforming acidic coiled-coil-containing protein 3 isoform 3
NM_001405351.1	NP_001392280.1	transforming acidic coiled-coil-containing protein 3 isoform 4
NM_001405352.1	NP_001392281.1	transforming acidic coiled-coil-containing protein 3 isoform 5
NM_001405353.1	NP_001392282.1	transforming acidic coiled-coil-containing protein 3 isoform 6
NM_001405354.1	NP_001392283.1	transforming acidic coiled-coil-containing protein 3 isoform 7
NM_001405355.1	NP_001392284.1	transforming acidic coiled-coil-containing protein 3 isoform 8
NM_001405356.1	NP_001392285.1	transforming acidic coiled-coil-containing protein 3 isoform 2
NM_001405357.1	NP_001392286.1	transforming acidic coiled-coil-containing protein 3 isoform 2
NM_001405358.1	NP_001392287.1	transforming acidic coiled-coil-containing protein 3 isoform 9
NM_001405360.1	NP_001392289.1	transforming acidic coiled-coil-containing protein 3 isoform 9

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15234987	MGI
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	17920017	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within astral microtubule organization	IDA IDA: Inferred from direct assay	17920017	MGI
acts upstream of or within cell population proliferation	IMP IMP: Inferred from mutant phenotype	17920017	MGI
acts upstream of or within cerebral cortex development	IMP IMP: Inferred from mutant phenotype	17920017	MGI
acts upstream of or within cytoplasmic sequestering of transcription factor	IDA IDA: Inferred from direct assay	11025203	MGI
acts upstream of or within hemopoiesis	IMP IMP: Inferred from mutant phenotype	11847113	MGI
acts upstream of or within interkinetic nuclear migration	IMP IMP: Inferred from mutant phenotype	17920017	MGI
acts upstream of or within microtubule cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	17920017	MGI
acts upstream of or within neurogenesis	IMP IMP: Inferred from mutant phenotype	17920017	MGI
acts upstream of or within regulation of cell cycle	IGI IGI: Inferred from genetic interaction	11847113	MGI
acts upstream of or within regulation of microtubule-based process	IMP IMP: Inferred from mutant phenotype	17920017	MGI
acts upstream of or within response to hypoxia	IDA IDA: Inferred from direct assay	11025203	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in centrosome	IDA IDA: Inferred from direct assay	11847113	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	11025203	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	11980711	MGI
is active in glutamatergic synapse	IEP IEP: Inferred from expression pattern	11980711	MGI
is active in postsynaptic density	IDA IDA: Inferred from direct assay	11980711	MGI
is active in postsynaptic density	IEP IEP: Inferred from expression pattern	11980711	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
transforming acidic coiled-coil-containing protein 3	ARNT-interacting protein

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (22)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-172158	ALKBH5-IN-5		99.66%	Unkown
HY-135960	BO-264		99.76%	Unkown
HY-10996A	KHS101 hydrochloride		99.65%	Unkown
HY-120087	KG-548	Inhibitor	99.90%	Unkown
HY-111876	SNIPER(TACC3)-1		98.67%	Unkown
HY-111877	SNIPER(TACC3)-2		99.54%	Unkown
HY-145895	SNIPER(TACC3)-11	Inhibitor	99.58%	Unkown
HY-W012248	KG-655	Inhibitor	99.87%	Unkown
HY-174981	LC-MF-4		98.05%	Unkown
HY-10996	KHS101		/	Unkown
HY-111876A	SNIPER(TACC3)-1 hydrochloride		/	Unkown
HY-111877A	SNIPER(TACC3)-2 hydrochloride		/	Unkown
HY-111886	KHS108-MV1		/	Unkown
HY-112500	Spindlactone B		/	Unkown
HY-151985	TACC3 inhibitor 1	Inducer	/	Unkown
HY-170960	TACC3 inhibitor 2		/	Unkown
HY-186208	TACC3-IN-3		/	Unkown
HY-186209	TACC3-IN-4		/	Unkown
HY-186210	TACC3-IN-5		/	Unkown
HY-RS14141	TACC3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS16930	Tacc3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23373	Tacc3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tacc3	NCBI	NCBI:10460