Tet2 - tet methylcytosine dioxygenase 2 Gene

Also Known as Ayu17-449; mKIAA1546; E130014J05Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 214133

Summary

Enables methylcytosine dioxygenase activity. Involved in cellular protein modification process; myeloid cell differentiation; and positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including DNA demethylation; animal organ development; and hematopoietic stem cell homeostasis. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including brain; extraembryonic component; lower urogenital tract; reproductive system; and urethra epithelium. Human ortholog(s) of this gene implicated in gastrointestinal system Cancer (multiple); hematologic Cancer (multiple); lung non-small cell carcinoma; and primary immunodeficiency disease. Orthologous to human TET2 (tet methylcytosine dioxygenase 2). [provided by Alliance of Genome Resources, Apr 2022]

Tet2 Products (2)

mRNA Protein Name
NM_001040400.2 NP_001035490.2 methylcytosine dioxygenase TET2 isoform 1
NM_001346736.1 NP_001333665.1 methylcytosine dioxygenase TET2 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables 5-methylcytosine dioxygenase activity IDA
IDA: Inferred from direct assay
19372391 MGI
enables 5-methylcytosine dioxygenase activity IMP
IMP: Inferred from mutant phenotype
21057493 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
23222540 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within chromosomal 5-methylcytosine DNA demethylation, oxidation pathway IMP
IMP: Inferred from mutant phenotype
21803851 MGI
acts upstream of or within cytosine metabolic process IMP
IMP: Inferred from mutant phenotype
21803851 MGI
acts upstream of or within hematopoietic stem cell homeostasis IMP
IMP: Inferred from mutant phenotype
21803851 MGI
acts upstream of or within hemoglobin metabolic process IMP
IMP: Inferred from mutant phenotype
21803851 MGI
acts upstream of or within hemopoiesis IMP
IMP: Inferred from mutant phenotype
21723200 MGI
acts upstream of or within homeostasis of number of cells IMP
IMP: Inferred from mutant phenotype
21803851 MGI
acts upstream of or within kidney development IMP
IMP: Inferred from mutant phenotype
18288583 MGI
acts upstream of or within liver morphogenesis IMP
IMP: Inferred from mutant phenotype
21803851 MGI
involved in myeloid cell differentiation IMP
IMP: Inferred from mutant phenotype
21057493 MGI
acts upstream of or within myeloid progenitor cell differentiation IMP
IMP: Inferred from mutant phenotype
21803851 MGI
acts upstream of or within positive regulation of gene expression via chromosomal CpG island demethylation IDA
IDA: Inferred from direct assay
20639862 MGI
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
23353889 MGI
acts upstream of or within post-embryonic development IMP
IMP: Inferred from mutant phenotype
18288583 MGI
involved in protein O-linked glycosylation IMP
IMP: Inferred from mutant phenotype
23353889 MGI
acts upstream of or within spleen development IMP
IMP: Inferred from mutant phenotype
21803851 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

methylcytosine dioxygenase TET2

  • probable methylcytosine dioxygenase TET2

  • tet oncogene 2

  • tet oncogene family member 2

Tet2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Tet2 Q4JK59 Ogt Mus musculus Q8CGY8
Anti Bait CoIP
23222540
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-111558 Bobcat339 Inhibitor 99.30% Unkown
HY-111558A Bobcat339 hydrochloride Inhibitor 99.62% Unkown
HY-402410 TETi76 Inhibitor 97.49% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tet2 NCBI NCBI:54790