Ogt - O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase) Gene

Also Known as Ogtl; 1110038P24Rik; 4831420N21Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 108155

Summary

Enables protein O-GlcNAc transferase activity. Involved in several processes, including circadian regulation of gene expression; positive regulation of cold-induced thermogenesis; and regulation of gluconeogenesis. Acts upstream of or within protein O-linked glycosylation. Predicted to be located in several cellular components, including euchromatin; neuronal cell body; and zymogen granule. Predicted to be part of Histone Acetyltransferase complex and protein N-acetylglucosaminyltransferase complex. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 106. Orthologous to human OGT (O-linked N-acetylglucosamine (GlcNAc) transferase). [provided by Alliance of Genome Resources, Apr 2022]

Ogt Products (2)

mRNA Protein Name
NM_001290535.1 NP_001277464.1 UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit isoform 2
NM_139144.4 NP_631883.2 UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables chromatin DNA binding IDA
IDA: Inferred from direct assay
22878500 MGI
enables protein O-acetylglucosaminyltransferase activity IDA
IDA: Inferred from direct assay
21471514 MGI
enables protein O-acetylglucosaminyltransferase activity IMP
IMP: Inferred from mutant phenotype
23395176 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
17670746 MGI
Biological Process GO Annotation Evidence References Source
involved in circadian regulation of gene expression IMP
IMP: Inferred from mutant phenotype
23395176 MGI
involved in hemopoiesis IMP
IMP: Inferred from mutant phenotype
33406421 MGI
involved in mitophagy IMP
IMP: Inferred from mutant phenotype
33406421 MGI
involved in negative regulation of protein ubiquitination IDA
IDA: Inferred from direct assay
23395176 MGI
involved in positive regulation of cold-induced thermogenesis IMP
IMP: Inferred from mutant phenotype
28637651 MGI
involved in positive regulation of lipid biosynthetic process IDA
IDA: Inferred from direct assay
21471514 MGI
involved in positive regulation of transcription from RNA polymerase II promoter by glucose IDA
IDA: Inferred from direct assay
21471514 MGI
acts upstream of or within protein O-linked glycosylation IDA
IDA: Inferred from direct assay
17670746 MGI
involved in regulation of gluconeogenesis IMP
IMP: Inferred from mutant phenotype
23395176 MGI
involved in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane IDA
IDA: Inferred from direct assay
28143929 MGI
involved in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane IEP
IEP: Inferred from expression pattern
28143929 MGI
involved in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane IMP
IMP: Inferred from mutant phenotype
28143929 MGI
involved in regulation of synapse assembly IDA
IDA: Inferred from direct assay
28143929 MGI
involved in regulation of synapse assembly IEP
IEP: Inferred from expression pattern
28143929 MGI
involved in regulation of synapse assembly IMP
IMP: Inferred from mutant phenotype
28143929 MGI
Cellular Component GO Annotation Evidence References Source
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
28143929 MGI
is active in glutamatergic synapse IEP
IEP: Inferred from expression pattern
28143929 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
28143929 MGI
is active in nucleus IDA
IDA: Inferred from direct assay
21471514 MGI
is active in synapse IDA
IDA: Inferred from direct assay
28143929 MGI
is active in synapse IEP
IEP: Inferred from expression pattern
28143929 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

  • O-GlcNAc transferase subunit p110

  • O-linked N-acetylglucosamine transferase 110 kDa subunit

Ogt Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Ogt Q8CGY8 Tet2 Mus musculus Q4JK59
Anti Bait CoIP
23222540
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (18)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-119738 OSMI-1 Inhibitor 99.88% Unkown
HY-145934 UDP-GalNAz disodium Substrate 99.89% Unkown
HY-114361 OSMI-4 Inhibitor 99.69% Unkown
HY-112174 UDP-GlcNAc disodium 99.92% Unkown
HY-145934A UDP-GlcNAz disodium Substrate 99.74% Unkown
HY-136282 ST045849 Inhibitor 99.96% Unkown
HY-N3677 Dammarenediol II Inhibitor 99.81% Unkown
HY-101548 OGT-IN-1 Inhibitor 98.14% Unkown
HY-139793 UDP-glucosamine disodium 99.44% Unkown
HY-135784 OSMI-2 Inhibitor 99.59% Unkown
HY-W039939 2-Azido-2-deoxy-D-glucose, 98% Substrate 98.0% Unkown
HY-119738A (Rac)-OSMI-1 Inhibitor 96.51% Unkown
HY-148113 PG 34 98.0% Unkown
HY-125278 OGT-IN-4 Inhibitor 99.65% Unkown
HY-145934B UDP-GlcNAz Substrate / Unkown
HY-135785 OSMI-3 Inhibitor 99.08% Unkown
HY-149552 Ac4-5SGlcNAc Inhibitor / Unkown
HY-W477597 BZX2 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ogt NCBI NCBI:8473