Tcf7 - transcription factor 7, T cell specific Gene

Also Known as Tcf1; TCF-1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 21414

Summary

This gene encodes a transcription factor which is a member of the T-cell specific transcription factor family. The encoded protein is distinct from the hepatic transcription factor, transcription factor 1, which is also referred to by the symbol Tcf1. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Sep 2015]

Tcf7 Products (2)

mRNA Protein Name
NM_001313981.1 NP_001300910.1 transcription factor 7
NM_009331.4 NP_033357.1 transcription factor 7

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
1827138 MGI
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
12235125 MGI
enables DNA-binding transcription repressor activity IMP
IMP: Inferred from mutant phenotype
17218525 MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IMP
IMP: Inferred from mutant phenotype
22723415 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
22723415 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
17218525 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within T cell receptor V(D)J recombination IGI
IGI: Inferred from genetic interaction
9462507 MGI
acts upstream of or within alpha-beta T cell differentiation IGI
IGI: Inferred from genetic interaction
9462507 MGI
involved in canonical Wnt signaling pathway IDA
IDA: Inferred from direct assay
12235125 MGI
involved in canonical Wnt signaling pathway involved in negative regulation of apoptotic process IDA
IDA: Inferred from direct assay
12235125 MGI
acts upstream of or within embryonic digestive tract morphogenesis IGI
IGI: Inferred from genetic interaction
15057272 MGI
acts upstream of or within embryonic genitalia morphogenesis IGI
IGI: Inferred from genetic interaction
15057272 MGI
acts upstream of or within embryonic hindgut morphogenesis IGI
IGI: Inferred from genetic interaction
15057272 MGI
involved in gamma-delta T cell differentiation IMP
IMP: Inferred from mutant phenotype
30413363 MGI
involved in negative regulation of apoptotic process IDA
IDA: Inferred from direct assay
12235125 MGI
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
22723415 MGI
acts upstream of or within neural tube development IGI
IGI: Inferred from genetic interaction
15057272 MGI
involved in regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
23562159 MGI
acts upstream of or within regulation of cell population proliferation IDA
IDA: Inferred from direct assay
12235125 MGI
involved in regulation of gamma-delta T cell differentiation IMP
IMP: Inferred from mutant phenotype
23562159 MGI
acts upstream of or within regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
12235125 MGI
Cellular Component GO Annotation Evidence References Source
located in euchromatin IDA
IDA: Inferred from direct assay
22723415 MGI
located in nucleus IDA
IDA: Inferred from direct assay
1827138 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

transcription factor 7

  • T-cell-specific transcription factor 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14308 TCF7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14309 TCF7L1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14310 TCF7L2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17858 Tcf7l2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20345 Tcf7 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24327 Tcf7l2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26854 Tcf7 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tcf7 NCBI NCBI:6932