Tead4 - TEA domain family member 4 Gene

Also Known as Tef3; Tefr; Etfr2; FR-19; Rtef1; TEF-3; Tefr1; ETFR-2; TEAD-4; Tefr1a; Tcf13r1

Species: Mus musculus

Gene Type: protein coding

Gene ID: 21679

Summary

This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain. It is preferentially expressed in the skeletal muscle, and binds to the M-CAT regulatory element found in promoters of muscle-specific genes to direct their gene expression. This factor may play a role in the embryonic development of skeletal muscle. Alternatively spliced transcripts encoding distinct isoforms, which are translated through the use of a non-AUG (AUU) initiation codon, have been described for this gene. [provided by RefSeq, Jul 2008]

Tead4 Products (2)

mRNA	Protein	Name
NM_001080979.1	NP_001074448.2	transcriptional enhancer factor TEF-3 isoform b
NM_011567.2	NP_035697.3	transcriptional enhancer factor TEF-3 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA binding	IDA IDA: Inferred from direct assay	8702974	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	16207754	MGI
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	26902285	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	8702974	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	22632831	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	22529382	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within blastocyst formation	IMP IMP: Inferred from mutant phenotype	18804437	MGI
acts upstream of or within cell fate commitment	IDA IDA: Inferred from direct assay	22529382	MGI
acts upstream of or within cell fate specification	IMP IMP: Inferred from mutant phenotype	18083014	MGI
acts upstream of or within embryo implantation	IMP IMP: Inferred from mutant phenotype	18083014	MGI
acts upstream of or within in utero embryonic development	IMP IMP: Inferred from mutant phenotype	18083014	MGI
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	26902285	MGI
acts upstream of or within positive regulation of stem cell population maintenance	IGI IGI: Inferred from genetic interaction	20516196	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16207754	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	16207754	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	22529382	MGI
acts upstream of or within regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	18083014	MGI
acts upstream of or within trophectodermal cell fate commitment	IMP IMP: Inferred from mutant phenotype	18083014	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	22529382	MGI
part of protein-DNA complex	IDA IDA: Inferred from direct assay	22529382	MGI
part of transcription regulator complex	IDA IDA: Inferred from direct assay	16207754	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
transcriptional enhancer factor TEF-3	ETF-related factor-2 FGF-regulated 19 RTEF-1 TEF-1-related factor 1 TEF-1-related factor FR-19

Recombinant Tead4 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71575	ETFR-2/TEAD-4 Protein, Mouse	Q62296-1 (R210-E427)	≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-172113	H122		98.33%	Phase 4

Pre-clinical Phase

Bioactive Molecules (20)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-125269	TED-347	Inhibitor	99.13%	Unkown
HY-139330	MGH-CP1	Inducer	99.56%	Unkown
HY-147135	MYF-03-69		98.11%	Unkown
HY-147136	MYF-03-176	Inhibitor	99.72%	Unkown
HY-186117	KG-FP-003	Degrader	/	Unkown
HY-147209	DC-TEAD3in03	Inhibitor	/	Unkown
HY-172932	TEAD-IN-20	Inhibitor	/	Unkown
HY-173139	TEAD-IN-19	Inhibitor	/	Unkown
HY-179706	VS3	Inhibitor	/	Unkown
HY-181534	PROTAC TEAD1/IAP degrader-1	Degrader	/	Unkown
HY-181594	PROTAC TEAD/IAP degrader-1	Degrader	/	Unkown
HY-183753	LC-TD-05		/	Unkown
HY-184225	PROTAC TEAD degrader-3	Degrader	/	Unkown
HY-186118	TEAD ligand 6	Ligand	/	Unkown
HY-187180	GNE-8025		/	Unkown
HY-187181	GNE-2181	Inhibitor	/	Unkown
HY-RS14345	TEAD4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-160657	DC-TEADin04		/	Unkown
HY-RS16870	Tead4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23311	Tead4 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tead4	NCBI	NCBI:7004