TEAD4 - TEA domain transcription factor 4 Gene

Also Known as TEF3; RTEF1; TEF-3; EFTR-2; TEFR-1; TCF13L1; hRTEF-1B

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7004

About TEAD4

Cytogenetic location: 12p13.33 Genomic coordinates (GRCh38): 12:2,959,397-3,040,676 (from NCBI)

This gene has 8 transcripts (splice variants), 194 orthologues and 3 paralogues. Ubiquitous expression in thyroid (RPKM 4.8), placenta (RPKM 4.3) and 23 other tissues.

Summary

This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain. It is preferentially expressed in the skeletal muscle, and binds to the M-CAT regulatory element found in promoters of muscle-specific genes to direct their gene expression. Alternatively spliced transcripts encoding distinct isoforms, some of which are translated through the use of a non-AUG (UUG) initiation codon, have been described for this gene. [provided by RefSeq, Jul 2008]

TEAD4 Products (3)

mRNA	Protein	Name
NM_003213.4	NP_003204.2	transcriptional enhancer factor TEF-3 isoform 1
NM_201441.3	NP_958849.1	transcriptional enhancer factor TEF-3 isoform 2
NM_201443.3	NP_958851.1	transcriptional enhancer factor TEF-3 isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	18579750	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in hippo signaling	IDA IDA: Inferred from direct assay	18579750	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	25796446	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TEAD4 Protein Structure

TEA

0
100
200
300
400
434 a.a.

Protein Preferred Names	Protein Names
transcriptional enhancer factor TEF-3	TEA domain family member 4

TEAD4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TEAD4	Q15561	KRT40	Homo sapiens	Q6A162	Y2H Array	32296183
Intra	TEAD4	Q15561	KRT40	Homo sapiens	Q6A162	Validated Y2H	26871637
Intra	TEAD4	Q15561	KRT40	Homo sapiens	Q6A162	Validated Y2H	32296183
Intra	TEAD4	Q15561	KRT40	Homo sapiens	Q6A162	Y2H Prey Pooling	26871637
Intra	TEAD4	Q15561	KRT40	Homo sapiens	Q6A162	Y2H Prey Pooling	32296183
Intra	TEAD4	Q15561	KRT40	Homo sapiens	Q6A162	Y2H Array	26871637
Intra	TEAD4	Q15561	HOMEZ	Homo sapiens	Q8IX15-3	Y2H Prey Pooling	26871637
Intra	TEAD4	Q15561	HOMEZ	Homo sapiens	Q8IX15-3	Validated Y2H	26871637
Intra	TEAD4	Q15561	HOMEZ	Homo sapiens	Q8IX15-3	Y2H Array	26871637
Intra	TEAD4	Q15561	YAP1	Homo sapiens	P46937	Comig Non-Denat Gel	26592798
Intra	TEAD4	Q15561	YAP1	Homo sapiens	P46937	ITC	26592798
Intra	TEAD4	Q15561	YAP1	Homo sapiens	P46937	BLI	24525233
Intra	TEAD4	Q15561	YAP1	Homo sapiens	P46937	Anti Tag CoIP	33961781
Intra	TEAD4	Q15561	YAP1	Homo sapiens	P46937	Pull Down	24525233
Intra	TEAD4	Q15561	MTUS2	Homo sapiens	Q5JR59-3	Y2H Array	32296183
Intra	TEAD4	Q15561	MTUS2	Homo sapiens	Q5JR59-3	Validated Y2H	26871637
Intra	TEAD4	Q15561	MTUS2	Homo sapiens	Q5JR59-3	Validated Y2H	32296183
Intra	TEAD4	Q15561	MTUS2	Homo sapiens	Q5JR59-3	Y2H Prey Pooling	26871637
Intra	TEAD4	Q15561	MTUS2	Homo sapiens	Q5JR59-3	Y2H Prey Pooling	32296183
Intra	TEAD4	Q15561	MTUS2	Homo sapiens	Q5JR59-3	Y2H Array	26871637
Intra	TEAD4	Q15561	TLE5	Homo sapiens	Q08117-2	Y2H Array	32296183
Intra	TEAD4	Q15561	TLE5	Homo sapiens	Q08117-2	Y2H Prey Pooling	32296183
Intra	TEAD4	Q15561	CDR2	Homo sapiens	Q01850	Y2H Prey Pooling	32296183
Intra	TEAD4	Q15561	CDR2	Homo sapiens	Q01850	Y2H Array	32296183
Intra	TEAD4	Q15561	VGLL3	Homo sapiens	A8MV65-2	Y2H Prey Pooling	32296183
Intra	TEAD4	Q15561	VGLL3	Homo sapiens	A8MV65-2	Y2H Array	32296183
Intra	TEAD4	Q15561	RUNDC3A	Homo sapiens	Q59EK9-3	Validated Y2H	26871637
Intra	TEAD4	Q15561	RUNDC3A	Homo sapiens	Q59EK9-3	Y2H Prey Pooling	26871637
Intra	TEAD4	Q15561	RUNDC3A	Homo sapiens	Q59EK9-3	Y2H Array	26871637
Intra	TEAD4	Q15561	CCDC125	Homo sapiens	Q86Z20	Validated Y2H	32296183
Intra	TEAD4	Q15561	CCDC125	Homo sapiens	Q86Z20	Y2H Array	32296183
Intra	TEAD4	Q15561	CCDC125	Homo sapiens	Q86Z20	Y2H Prey Pooling	32296183
Intra	TEAD4	Q15561	VGLL1	Homo sapiens	Q99990	Y2H Prey Pooling	32296183
Intra	TEAD4	Q15561	VGLL1	Homo sapiens	Q99990	Validated Y2H	32296183
Intra	TEAD4	Q15561	VGLL1	Homo sapiens	Q99990	Y2H Array	32296183
Intra	TEAD4	Q15561	RUNX1	Homo sapiens	Q01196-8	Y2H Array	32296183
Intra	TEAD4	Q15561	RUNX1	Homo sapiens	Q01196-8	Y2H Prey Pooling	32296183
Intra	TEAD4	Q15561	TRIM54	Homo sapiens	Q9BYV2	Y2H Prey Pooling	32296183
Intra	TEAD4	Q15561	TRIM54	Homo sapiens	Q9BYV2	Y2H Array	32296183
Intra	TEAD4	Q15561	TRIM54	Homo sapiens	Q9BYV2	Validated Y2H	32296183
Intra	TEAD4	Q15561	HAUS1	Homo sapiens	Q96CS2	Y2H Prey Pooling	32296183
Intra	TEAD4	Q15561	HAUS1	Homo sapiens	Q96CS2	Validated Y2H	32296183
Intra	TEAD4	Q15561	HAUS1	Homo sapiens	Q96CS2	Y2H Array	32296183
Intra	TEAD4	Q15561	CCDC172	Homo sapiens	P0C7W6	Y2H Array	26871637
Intra	TEAD4	Q15561	CCDC172	Homo sapiens	P0C7W6	Validated Y2H	26871637
Intra	TEAD4	Q15561	CCDC172	Homo sapiens	P0C7W6	Y2H Prey Pooling	26871637
Intra	TEAD4	Q15561	VPS52	Homo sapiens	Q8N1B4	Y2H Array	26871637
Intra	TEAD4	Q15561	VPS52	Homo sapiens	Q8N1B4	Y2H Prey Pooling	26871637
Intra	TEAD4	Q15561	VPS52	Homo sapiens	Q8N1B4	Validated Y2H	26871637
Intra	TEAD4	Q15561	PRKAR1B	Homo sapiens	P31321	Y2H Array	32296183
Intra	TEAD4	Q15561	PRKAR1B	Homo sapiens	P31321	Y2H Prey Pooling	32296183
Intra	TEAD4	Q15561	PNMA1	Homo sapiens	Q8ND90	Y2H Prey Pooling	26871637
Intra	TEAD4	Q15561	PNMA1	Homo sapiens	Q8ND90	Y2H Array	26871637
Intra	TEAD4	Q15561	PNMA1	Homo sapiens	Q8ND90	Validated Y2H	26871637
Intra	TEAD4	Q15561	KRT27	Homo sapiens	Q7Z3Y8	Validated Y2H	32296183
Intra	TEAD4	Q15561	KRT27	Homo sapiens	Q7Z3Y8	Y2H Array	32296183
Intra	TEAD4	Q15561	KRT27	Homo sapiens	Q7Z3Y8	Y2H Prey Pooling	32296183
Intra	TEAD4	Q15561	TRAF1	Homo sapiens	Q13077	Y2H Prey Pooling	26871637
Intra	TEAD4	Q15561	TRAF1	Homo sapiens	Q13077	Y2H Array	26871637
Intra	TEAD4	Q15561	TRAF1	Homo sapiens	Q13077	Y2H Prey Pooling	32296183
Intra	TEAD4	Q15561	TRAF1	Homo sapiens	Q13077	Validated Y2H	26871637
Intra	TEAD4	Q15561	TRAF1	Homo sapiens	Q13077	Y2H Array	32296183
Intra	TEAD4	Q15561	PRDM14	Homo sapiens	Q9GZV8	Y2H Prey Pooling	32296183
Intra	TEAD4	Q15561	PRDM14	Homo sapiens	Q9GZV8	Validated Y2H	32296183
Intra	TEAD4	Q15561	PRDM14	Homo sapiens	Q9GZV8	Y2H Array	32296183
Intra	TEAD4	Q15561	VGLL4	Homo sapiens	Q14135	Pull Down	24525233
Intra	TEAD4	Q15561	VGLL4	Homo sapiens	Q14135	Anti Tag CoIP	24525233
Intra	TEAD4	Q15561	GOLGA6L9	Homo sapiens	A6NEM1	Y2H Prey Pooling	32296183
Intra	TEAD4	Q15561	GOLGA6L9	Homo sapiens	A6NEM1	Y2H Array	32296183
Intra	TEAD4	Q15561	SESTD1	Homo sapiens	Q86VW0	Validated Y2H	32296183
Intra	TEAD4	Q15561	SESTD1	Homo sapiens	Q86VW0	Y2H Array	32296183
Intra	TEAD4	Q15561	SESTD1	Homo sapiens	Q86VW0	Y2H Prey Pooling	32296183
Intra	TEAD4	Q15561	GOLGA2	Homo sapiens	Q08379	Validated Y2H	26871637
Intra	TEAD4	Q15561	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	26871637
Intra	TEAD4	Q15561	GOLGA2	Homo sapiens	Q08379	Y2H Array	26871637
Intra	TEAD4	Q15561	GOLGA2	Homo sapiens	Q08379	Y2H Array	32296183
Intra	TEAD4	Q15561	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	32296183
Intra	TEAD4	Q15561	INCA1	Homo sapiens	Q0VD86	Y2H Array	32296183
Intra	TEAD4	Q15561	INCA1	Homo sapiens	Q0VD86	Y2H Prey Pooling	32296183
Intra	TEAD4	Q15561	RASSF10	Homo sapiens	A6NK89	Y2H Array	32296183
Intra	TEAD4	Q15561	RASSF10	Homo sapiens	A6NK89	Y2H Prey Pooling	32296183
Intra	TEAD4	Q15561	SAT1	Homo sapiens	P21673	Y2H Array	32296183
Intra	TEAD4	Q15561	SAT1	Homo sapiens	P21673	Y2H Prey Pooling	32296183
Intra	TEAD4	Q15561	TRIM27	Homo sapiens	P14373	Y2H Array	26871637
Intra	TEAD4	Q15561	TRIM27	Homo sapiens	P14373	Y2H Array	32296183
Intra	TEAD4	Q15561	TRIM27	Homo sapiens	P14373	Y2H Prey Pooling	26871637
Intra	TEAD4	Q15561	TRIM27	Homo sapiens	P14373	Y2H Prey Pooling	32296183
Intra	TEAD4	Q15561	TRIM27	Homo sapiens	P14373	Validated Y2H	26871637
Intra	TEAD4	Q15561	VTA1	Homo sapiens	Q9NP79	Anti Tag CoIP	28514442
Intra	TEAD4	Q15561	VTA1	Homo sapiens	Q9NP79	Y2H Prey Pooling	32296183
Intra	TEAD4	Q15561	VTA1	Homo sapiens	Q9NP79	Validated Y2H	32296183
Intra	TEAD4	Q15561	VTA1	Homo sapiens	Q9NP79	Y2H Array	32296183
Intra	TEAD4	Q15561	DYDC1	Homo sapiens	Q8WWB3	Validated Y2H	32296183
Intra	TEAD4	Q15561	DYDC1	Homo sapiens	Q8WWB3	Y2H Array	32296183
Intra	TEAD4	Q15561	DYDC1	Homo sapiens	Q8WWB3	Y2H Prey Pooling	32296183
Intra	TEAD4	Q15561	LDOC1	Homo sapiens	O95751	Y2H Prey Pooling	32296183
Intra	TEAD4	Q15561	LDOC1	Homo sapiens	O95751	Y2H Array	32296183
Intra	TEAD4	Q15561	LZTS2	Homo sapiens	Q9BRK4	Y2H Prey Pooling	32296183
Intra	TEAD4	Q15561	LZTS2	Homo sapiens	Q9BRK4	Validated Y2H	32296183
Intra	TEAD4	Q15561	LZTS2	Homo sapiens	Q9BRK4	Y2H Array	32296183
Intra	TEAD4	Q15561	SORBS3	Homo sapiens	O60504	Y2H Array	32296183
Intra	TEAD4	Q15561	SORBS3	Homo sapiens	O60504	Y2H Prey Pooling	32296183
Intra	TEAD4	Q15561	WWTR1	Homo sapiens	Q9GZV5	Anti Tag CoIP	33961781
Intra	TEAD4	Q15561	WWTR1	Homo sapiens	Q9GZV5	Y2H Prey Pooling	32296183
Intra	TEAD4	Q15561	WWTR1	Homo sapiens	Q9GZV5	Anti Tag CoIP	28514442
Intra	TEAD4	Q15561	WWTR1	Homo sapiens	Q9GZV5	Y2H Pooling	16189514
Intra	TEAD4	Q15561	WWTR1	Homo sapiens	Q9GZV5	Y2H Array	32296183
Intra	TEAD4	Q15561	WWTR1	Homo sapiens	Q9GZV5	Anti Tag CoIP	20972459
Intra	TEAD4	Q15561	WWTR1	Homo sapiens	Q9GZV5	Y2H Array	31515488
Intra	TEAD4	Q15561	WWTR1	Homo sapiens	Q9GZV5	Validated Y2H	32296183
Intra	TEAD4	Q15561	CEP55	Homo sapiens	Q53EZ4	Validated Y2H	32296183
Intra	TEAD4	Q15561	CEP55	Homo sapiens	Q53EZ4	Y2H Array	31515488
Intra	TEAD4	Q15561	CEP55	Homo sapiens	Q53EZ4	Y2H Prey Pooling	32296183
Intra	TEAD4	Q15561	CEP55	Homo sapiens	Q53EZ4	Y2H Array	32296183
Intra	TEAD4	Q15561	CEP55	Homo sapiens	Q53EZ4	Y2H	21516116
Cross	TEAD4	Q15561	Vgll4	Mus musculus	Q80V24	Pull Down	24525233
Intra	TEAD4	Q15561	KRT31	Homo sapiens	Q15323	Y2H Array	32296183
Intra	TEAD4	Q15561	KRT31	Homo sapiens	Q15323	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant TEAD4 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71535	TEAD4 Protein, Human (His)	Q15561 (M74-E434)	≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Sveinsson Chorioretinal Atrophy	SCRA Atrophia Areata Helicoid Peripapillary Chorioretinal Degeneration Hpcd Aa Peripapillary Chorioretinal Degeneration, Icelandic Type Helicoidal Peripapillary Chorioretinal Degeneration Atrophy, Chorioretinal, Sveinsson
Meningioma, Familial	Meningioma Familial Meningioma Meningioma, Familial, Susceptibility To Meningeal Neoplasm Meningeal Neoplasms Meningiomas Meningioma, Nf2-Related, Somatic Meningioma, Sis-Related Meningothelial Cell Tumor Neoplasm Of The Meninges Primary Meningeal Tumor Familial Multiple Meningioma MNGMA Meningioma, Benign, No Icd-O Subtype Intracranial Meningioma Meningothelial Cell Neoplasm Supratentorial Meningioma Primary Neoplasm Of Spinal Meninges Benign Intracranial Meningioma Benign Meningioma Meningeal Tumours Meningeal Sarcoma Of Unspecified Site Meningothelial Sarcoma Of Unspecified Site

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-172113	H122		98.33%	Phase 4

Pre-clinical Phase

Bioactive Molecules (20)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-125269	TED-347	Inhibitor	99.13%	Unkown
HY-139330	MGH-CP1	Inducer	99.56%	Unkown
HY-147135	MYF-03-69		98.11%	Unkown
HY-147136	MYF-03-176	Inhibitor	99.72%	Unkown
HY-186117	KG-FP-003	Degrader	/	Unkown
HY-147209	DC-TEAD3in03	Inhibitor	/	Unkown
HY-172932	TEAD-IN-20	Inhibitor	/	Unkown
HY-173139	TEAD-IN-19	Inhibitor	/	Unkown
HY-179706	VS3	Inhibitor	/	Unkown
HY-181534	PROTAC TEAD1/IAP degrader-1	Degrader	/	Unkown
HY-181594	PROTAC TEAD/IAP degrader-1	Degrader	/	Unkown
HY-183753	LC-TD-05		/	Unkown
HY-184225	PROTAC TEAD degrader-3	Degrader	/	Unkown
HY-186118	TEAD ligand 6	Ligand	/	Unkown
HY-187180	GNE-8025		/	Unkown
HY-187181	GNE-2181	Inhibitor	/	Unkown
HY-RS14345	TEAD4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-160657	DC-TEADin04		/	Unkown
HY-RS16870	Tead4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23311	Tead4 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	TEAD4	VGNC	VGNC:35727
Macaca mulatta	TEAD4	VGNC	VGNC:78304
Felis catus	TEAD4	VGNC	VGNC:66056
Mus musculus	TEAD4	MGD	MGI:106907
Rattus norvegicus	TEAD4	RGD	RGD:1585671
Canis familiaris	TEAD4	VGNC	VGNC:57446
Others	TEAD4	NCBI