Tek - TEK receptor tyrosine kinase Gene

Also Known as Hyk; STK1; Tie2; Tie-2; Cd202b

Species: Mus musculus

Gene Type: protein coding
Gene ID: 21687

Summary

Enables protein tyrosine kinase activity and signaling receptor activity. Involved in several processes, including circulatory system development; negative regulation of endothelial cell apoptotic process; and response to retinoic acid. Acts upstream of or within several processes, including positive regulation of macromolecule metabolic process; positive regulation of protein import into nucleus; and regulation of NIK/NF-kappaB signaling. Located in perinuclear region of cytoplasm. Is expressed in several structures, including cardiovascular system; central nervous system; extraembryonic component; genitourinary system; and hemolymphoid system gland. Human ortholog(s) of this gene implicated in arteriovenous malformation and multiple cutaneous and mucosal venous malformations. Orthologous to human TEK (TEK receptor tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Tek Products (3)

mRNA Protein Name
NM_001290549.1 NP_001277478.1 angiopoietin-1 receptor isoform 2 precursor
NM_001290551.1 NP_001277480.1 angiopoietin-1 receptor isoform 3
NM_013690.3 NP_038718.2 angiopoietin-1 receptor isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
9204896 MGI
enables protein tyrosine kinase activity IDA
IDA: Inferred from direct assay
7958865 MGI
enables signaling receptor activity IPI
IPI: Inferred from physical interaction
8980223 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within angiogenesis IMP
IMP: Inferred from mutant phenotype
9846489 MGI
involved in angiogenesis IMP
IMP: Inferred from mutant phenotype
7596437 MGI
acts upstream of or within cell-cell adhesion IMP
IMP: Inferred from mutant phenotype
9683559 MGI
acts upstream of or within cell-matrix adhesion IMP
IMP: Inferred from mutant phenotype
9683559 MGI
involved in endothelial cell proliferation IMP
IMP: Inferred from mutant phenotype
7958865 MGI
involved in heart development IMP
IMP: Inferred from mutant phenotype
7958865 MGI
involved in heart trabecula formation IMP
IMP: Inferred from mutant phenotype
7958865 MGI
acts upstream of or within hemopoiesis IMP
IMP: Inferred from mutant phenotype
9846489 MGI
acts upstream of or within negative regulation of apoptotic process IGI
IGI: Inferred from genetic interaction
19409199 MGI
involved in negative regulation of endothelial cell apoptotic process IMP
IMP: Inferred from mutant phenotype
11375937 MGI
involved in peptidyl-tyrosine phosphorylation IDA
IDA: Inferred from direct assay
7958865 MGI
acts upstream of or within positive regulation of cell adhesion IMP
IMP: Inferred from mutant phenotype
15260986 MGI
acts upstream of or within positive regulation of cytokine production involved in immune response IDA
IDA: Inferred from direct assay
20060382 MGI
acts upstream of or within positive regulation of peptidyl-serine phosphorylation IGI
IGI: Inferred from genetic interaction
19409199 MGI
acts upstream of or within positive regulation of protein import into nucleus IDA
IDA: Inferred from direct assay
20060382 MGI
acts upstream of or within positive regulation of protein phosphorylation IDA
IDA: Inferred from direct assay
20060382 MGI
acts upstream of or within regulation of angiogenesis IMP
IMP: Inferred from mutant phenotype
9683559 MGI
acts upstream of or within regulation of cell migration IDA
IDA: Inferred from direct assay
20060382 MGI
acts upstream of or within regulation of cell migration IMP
IMP: Inferred from mutant phenotype
9683559 MGI
acts upstream of or within regulation of non-canonical NF-kappaB signal transduction IGI
IGI: Inferred from genetic interaction
20060382 MGI
involved in response to retinoic acid IDA
IDA: Inferred from direct assay
18439490 MGI
involved in vasculogenesis IMP
IMP: Inferred from mutant phenotype
7958865 MGI
Cellular Component GO Annotation Evidence References Source
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
20060382 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

angiopoietin-1 receptor

  • endothelial tyrosine kinase

  • endothelial-specific receptor tyrosine kinase

  • p140 TEK

  • tunica interna endothelial cell kinase

  • tyrosine kinase with Ig and EGF homology domains-2

  • tyrosine-protein kinase receptor TEK

  • tyrosine-protein kinase receptor TIE-2

Recombinant Tek Proteins

Cat. No. Product Name Accession Purity
HY-P73436 TIE-2 Protein, Mouse (Inactive, sf9, His-GST) Q02858 (Q770-A1122) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P73437 TIE-2 Protein, Mouse (HEK293, Fc) NP_038718.2 (A23-K744) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P73610 TIE-2 Protein, Mouse (HEK293, His) B1AWS8 (A23-K744) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-15514A Merestinib dihydrochloride Inhibitor 99.36% Phase 2

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-15514 Merestinib Inhibitor 99.99% Yes
HY-RS14355 TEK Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18596 Tek Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25081 Tek Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tek NCBI NCBI:7010