Tfam - transcription factor A, mitochondrial Gene

Also Known as Hmgts; mtTFA; tsHMG

Species: Mus musculus

Gene Type: protein coding
Gene ID: 21780

Summary

Enables mitochondrial promoter sequence-specific DNA binding activity. Involved in mitochondrial transcription. Acts upstream of or within mitochondrial respiratory chain complex assembly. Located in mitochondrial nucleoid. Is expressed in several structures, including brain; branchial arch; early conceptus; genitourinary system; and hemolymphoid system. Used to study Kearns-Sayre syndrome and Parkinson's disease. Human ortholog(s) of this gene implicated in Alzheimer's disease; Huntington's disease; Parkinson's disease; amyotrophic lateral sclerosis; and mitochondrial DNA depletion syndrome 15. Orthologous to human TFAM (transcription factor A, mitochondrial). [provided by Alliance of Genome Resources, Apr 2022]

Tfam Products (1)

mRNA Protein Name
NM_009360.4 NP_033386.1 transcription factor A, mitochondrial precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables mitochondrial promoter sequence-specific DNA binding IDA
IDA: Inferred from direct assay
2628167 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within mitochondrial respiratory chain complex assembly IMP
IMP: Inferred from mutant phenotype
11259653 MGI
involved in mitochondrial transcription IDA
IDA: Inferred from direct assay
2628167 MGI
Cellular Component GO Annotation Evidence References Source
located in mitochondrial nucleoid IDA
IDA: Inferred from direct assay
24703694 MGI
is active in mitochondrion IDA
IDA: Inferred from direct assay
2628167 MGI
located in mitochondrion IDA
IDA: Inferred from direct assay
8673128 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

transcription factor A, mitochondrial

  • TS-HMG

  • testis-specific HMG-box protein m-tsHMG

  • testis-specific high mobility group protein

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-W011725 N-6-Methyl-2-deoxyadenosine Inhibitor 99.83% Unkown
HY-175739 TFAM activator 1 99.25% Unkown
HY-RS14407 TFAM Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-N3225 Myricanol 98.93% Unkown
HY-RS17056 Tfam Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23500 Tfam Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tfam NCBI NCBI:7019