Thpo - thrombopoietin Gene

Also Known as Ml; Tpo; Mgdf; Mpllg

Species: Mus musculus

Gene Type: protein coding
Gene ID: 21832

Summary

This gene encodes a humoral growth factor necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis. The encoded protein is a ligand for the product of the myeloproliferative leukemia virus oncogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]

Thpo Products (4)

mRNA Protein Name
NM_001173505.1 NP_001166976.1 thrombopoietin isoform 1 precursor
NM_001289894.1 NP_001276823.1 thrombopoietin isoform 2 precursor
NM_001289896.1 NP_001276825.1 thrombopoietin isoform 3 precursor
NM_009379.3 NP_033405.1 thrombopoietin isoform 1 precursor

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
acts upstream of or within myeloid cell differentiation IDA
IDA: Inferred from direct assay
12393382 MGI
involved in positive regulation of ERK1 and ERK2 cascade IDA
IDA: Inferred from direct assay
22128142 MGI
involved in positive regulation of megakaryocyte differentiation IDA
IDA: Inferred from direct assay
22128142 MGI
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
IDA: Inferred from direct assay
22128142 MGI
involved in positive regulation of protein phosphorylation IDA
IDA: Inferred from direct assay
22128142 MGI
involved in thrombopoietin-mediated signaling pathway IDA
IDA: Inferred from direct assay
22128142 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

thrombopoietin

  • C-mpl ligand

  • megakaryocyte colony-stimulating factor

  • megakaryocyte growth and development factor

  • myeloproliferative leukemia virus oncogene ligand

Recombinant Thpo Proteins

Cat. No. Product Name Accession Purity
HY-P7088 TPO/Thrombopoietin Protein, Mouse (CHO) P40226-1 (S22-T356) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P70686 TPO/Thrombopoietin Protein, Mouse (HEK293, N-His) P40226-1 (S22-T356) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P70686A TPO/Thrombopoietin Protein, Mouse (HEK293, C-His) P40226-1 (S22-T356) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14498 THPO Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17819 Thpo Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Thpo NCBI NCBI:7066