Trim28 - tripartite motif-containing 28 Gene

Also Known as KAP-1; Tif1b; KRIP-1; MommeD9; Tif1beta

Species: Mus musculus

Gene Type: protein coding
Gene ID: 21849

Summary

Enables DNA binding activity; protein kinase activity; and transcription coactivator activity. Involved in epithelial to mesenchymal transition and positive regulation of DNA methylation-dependent heterochromatin assembly. Acts upstream of or within several processes, including DNA methylation involved in embryo development; negative regulation of single stranded viral RNA replication via double stranded DNA intermediate; and regulation of nucleobase-containing compound metabolic process. Located in euchromatin; heterochromatin; and nucleoplasm. Part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including branchial arch; central nervous system; early conceptus; genitourinary system; and limb primordium. Orthologous to human TRIM28 (tripartite motif containing 28). [provided by Alliance of Genome Resources, Apr 2022]

Trim28 Products (1)

mRNA Protein Name
NM_011588.3 NP_035718.2 transcription intermediary factor 1-beta

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
22442485 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
8978696 MGI
enables protein kinase activity IDA
IDA: Inferred from direct assay
10562550 MGI
enables transcription coactivator activity IDA
IDA: Inferred from direct assay
11331592 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within convergent extension involved in axis elongation IMP
IMP: Inferred from mutant phenotype
22110054 MGI
acts upstream of or within embryo implantation IMP
IMP: Inferred from mutant phenotype
22442485 MGI
acts upstream of or within embryonic placenta morphogenesis IMP
IMP: Inferred from mutant phenotype
22110054 MGI
acts upstream of or within epigenetic programming of gene expression IMP
IMP: Inferred from mutant phenotype
22442485 MGI
involved in epithelial to mesenchymal transition IDA
IDA: Inferred from direct assay
17273560 MGI
acts upstream of or within genomic imprinting IMP
IMP: Inferred from mutant phenotype
22442485 MGI
acts upstream of or within in utero embryonic development IMP
IMP: Inferred from mutant phenotype
22442485 MGI
acts upstream of or within innate immune response IDA
IDA: Inferred from direct assay
19270682 MGI
acts upstream of or within innate immune response IGI
IGI: Inferred from genetic interaction
19270682 MGI
acts upstream of or within negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
10562550 MGI
involved in negative regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
21518874 MGI
acts upstream of or within negative regulation of single stranded viral RNA replication via double stranded DNA intermediate IDA
IDA: Inferred from direct assay
19270682 MGI
acts upstream of or within negative regulation of single stranded viral RNA replication via double stranded DNA intermediate IGI
IGI: Inferred from genetic interaction
19270682 MGI
acts upstream of or within negative regulation of single stranded viral RNA replication via double stranded DNA intermediate IMP
IMP: Inferred from mutant phenotype
19270682 MGI
involved in negative regulation of single stranded viral RNA replication via double stranded DNA intermediate IMP
IMP: Inferred from mutant phenotype
20164836 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
8986806 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
22110054 MGI
acts upstream of or within positive regulation of DNA binding IDA
IDA: Inferred from direct assay
19270682 MGI
acts upstream of or within positive regulation of DNA binding IMP
IMP: Inferred from mutant phenotype
19270682 MGI
involved in positive regulation of DNA methylation-dependent heterochromatin formation IMP
IMP: Inferred from mutant phenotype
20164836 MGI
acts upstream of or within positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
11331592 MGI
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
17273560 MGI
acts upstream of or within protein autophosphorylation IDA
IDA: Inferred from direct assay
10562550 MGI
acts upstream of or within protein phosphorylation IDA
IDA: Inferred from direct assay
10562550 MGI
Cellular Component GO Annotation Evidence References Source
part of RNA polymerase II transcription regulator complex IDA
IDA: Inferred from direct assay
17273560 MGI
located in chromatin IDA
IDA: Inferred from direct assay
11331580 MGI
located in euchromatin IDA
IDA: Inferred from direct assay
10562550 MGI
located in heterochromatin IDA
IDA: Inferred from direct assay
10562550 MGI
NOT located in nucleolus IDA
IDA: Inferred from direct assay
10562550 MGI
located in nucleoplasm IDA
IDA: Inferred from direct assay
10562550 MGI
located in nucleus IDA
IDA: Inferred from direct assay
15469996 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

transcription intermediary factor 1-beta

  • E3 SUMO-protein ligase TRIM28

  • KRAB-A-interacting protein

  • RING-type E3 ubiquitin transferase TIF1-beta

  • TIF1-beta

  • transcriptional intermediary factor 1, beta

  • tripartite motif protein 28

  • tripartite motif-containing protein 28

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-169087 MJBIA9836 99.67% Unkown
HY-RS15033 TRIM28 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-169086 KL-465 / Unkown
HY-175240 PROTAC BRD4 Degrader-38 Degrader / Unkown
HY-181157 T/E PPI-IN-1 Inhibitor / Unkown
HY-RS18012 Trim28 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24485 Trim28 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Trim28 NCBI NCBI:10155