Tlr1 - toll-like receptor 1 Gene

Predicted to enable several functions, including Toll-like Receptor 2 binding activity; identical protein binding activity; and Lipopeptide binding activity. Involved in positive regulation of interleukin-6 production and positive regulation of tumor necrosis factor production. Acts upstream of or within defense response. Predicted to be located in Golgi apparatus and membrane raft. Predicted to be part of Toll-like Receptor 1-Toll-like receptor 2 protein complex. Predicted to be integral component of plasma membrane. Is expressed in cerebral cortex and telencephalon. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; aspergillosis; leprosy; pyelonephritis; and tuberculosis. Orthologous to human TLR1 (toll like receptor 1). [provided by Alliance of Genome Resources, Apr 2022]