RTKN2 - rhotekin 2 Gene

Also Known as PLEKHK1; bA531F24.1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 219790

About RTKN2

Cytogenetic location: 10q21.2 Genomic coordinates (GRCh38): 10:62,183,900-62,268,844 (from NCBI)

This gene has 3 transcripts (splice variants), 199 orthologues and 2 paralogues. Biased expression in lung (RPKM 32.1) and testis (RPKM 2.2).

Summary

Involved in negative regulation of intrinsic apoptotic signaling pathway; positive regulation of NF-kappaB transcription factor activity; and positive regulation of NIK/NF-kappaB signaling. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

RTKN2 Products (2)

mRNA Protein Name
NM_001282941.2 NP_001269870.1 rhotekin-2 isoform 2
NM_145307.4 NP_660350.2 rhotekin-2 isoform 1

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in negative regulation of intrinsic apoptotic signaling pathway IMP
IMP: Inferred from mutant phenotype
26124677 GOA
involved in positive regulation of NF-kappaB transcription factor activity IMP
IMP: Inferred from mutant phenotype
26124677 GOA
involved in positive regulation of non-canonical NF-kappaB signal transduction IMP
IMP: Inferred from mutant phenotype
26124677 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
15504364 GOA
located in nucleus IDA
IDA: Inferred from direct assay
15504364 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RTKN2 Protein Structure

Anillin

Anillin: Cell division protein anillin (97 - 247)

PH

PH: PH domain (290 - 388)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 609 a.a.
Protein Preferred Names Protein Names

rhotekin-2

  • PH domain-containing family K member 1

RTKN2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P810084 Rhotekin 2 Antibody (YA9428) WB, ICC/IF, IF-Tissue, IHC-P, IP, ELISA human

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12321 RTKN2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus RTKN2 VGNC VGNC:64808
Canis familiaris RTKN2 VGNC VGNC:45790
Bos taurus RTKN2 VGNC VGNC:34198
Macaca mulatta RTKN2 VGNC VGNC:77055
Mus musculus RTKN2 MGD MGI:2158417
Rattus norvegicus RTKN2 RGD RGD:1304834
Others RTKN2 NCBI