Twist1 - twist basic helix-loop-helix transcription factor 1 Gene

Also Known as Pde; pdt; Ska10; Twist; M-Twist; bHLHa38; Ska

Species: Mus musculus

Gene Type: protein coding
Gene ID: 22160

Summary

Basic helix-loop-helix (bHLH) transcription factors have been implicated in cell lineage determination and differentiation. This gene encodes a bHLH transcription factor that is evolutionarily conserved from invertebrates to humans, and was originally identified in Drosophila as an essential gene involved in early mesoderm development and dorsal-ventral patterning in the embryo. This protein plays a role in Cancer by regulating the epithelial-mesenchymal transition (EMT), a process that is critical for metastasis initiation, and promoting tumor progression. Mutations in the human gene are associated with Saethre-Chotzen syndrome (SCS). Mice with heterozygous mutations in this gene exhibit cranofacial and structural defects similar to those seen in human SCS patients. [provided by RefSeq, Sep 2015]

Twist1 Products (1)

mRNA Protein Name
NM_011658.2 NP_035788.1 twist-related protein 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
17893140 MGI
enables E-box binding IDA
IDA: Inferred from direct assay
16502419 MGI
enables E-box binding IMP
IMP: Inferred from mutant phenotype
24011070 MGI
enables bHLH transcription factor binding IPI
IPI: Inferred from physical interaction
23395635 MGI
enables histone deacetylase binding IDA
IDA: Inferred from direct assay
19345188 MGI
enables identical protein binding IPI
IPI: Inferred from physical interaction
16502419 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
16502419 MGI
enables protein domain specific binding IPI
IPI: Inferred from physical interaction
15030764 MGI
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
16502419 MGI
enables transcription coregulator binding IPI
IPI: Inferred from physical interaction
19345188 MGI
Biological Process GO Annotation Evidence References Source
involved in aortic valve morphogenesis IMP
IMP: Inferred from mutant phenotype
20804746 MGI
acts upstream of or within cardiac neural crest cell development involved in outflow tract morphogenesis IMP
IMP: Inferred from mutant phenotype
18539270 MGI
acts upstream of or within cardiac neural crest cell migration involved in outflow tract morphogenesis IMP
IMP: Inferred from mutant phenotype
18539270 MGI
involved in cell proliferation involved in heart valve development IMP
IMP: Inferred from mutant phenotype
20804746 MGI
involved in cellular response to hypoxia IMP
IMP: Inferred from mutant phenotype
18297062 MGI
acts upstream of or within cranial suture morphogenesis IMP
IMP: Inferred from mutant phenotype
12221714 MGI
involved in cranial suture morphogenesis IMP
IMP: Inferred from mutant phenotype
16502419 MGI
acts upstream of or within embryonic cranial skeleton morphogenesis IGI
IGI: Inferred from genetic interaction
15030764 MGI
involved in embryonic cranial skeleton morphogenesis IMP
IMP: Inferred from mutant phenotype
8988167 MGI
acts upstream of or within embryonic digit morphogenesis IMP
IMP: Inferred from mutant phenotype
15030764 MGI
acts upstream of or within embryonic forelimb morphogenesis IMP
IMP: Inferred from mutant phenotype
12175489 MGI
involved in embryonic hindlimb morphogenesis IMP
IMP: Inferred from mutant phenotype
8988167 MGI
acts upstream of or within embryonic limb morphogenesis IMP
IMP: Inferred from mutant phenotype
11350121 MGI
acts upstream of or within embryonic skeletal system morphogenesis IMP
IMP: Inferred from mutant phenotype
15030764 MGI
acts upstream of or within endocardial cushion morphogenesis IMP
IMP: Inferred from mutant phenotype
18539270 MGI
acts upstream of energy homeostasis IDA
IDA: Inferred from direct assay
19345188 MGI
acts upstream of or within hindlimb morphogenesis IMP
IMP: Inferred from mutant phenotype
10700192 MGI
acts upstream of or within in utero embryonic development IMP
IMP: Inferred from mutant phenotype
15030764 MGI
acts upstream of macrophage cytokine production IGI
IGI: Inferred from genetic interaction
16831897 MGI
involved in mitral valve morphogenesis IMP
IMP: Inferred from mutant phenotype
20804746 MGI
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
14645221 MGI
acts upstream of or within negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
12175489 MGI
involved in negative regulation of cell differentiation IDA
IDA: Inferred from direct assay
9520323 MGI
acts upstream of or within negative regulation of macrophage cytokine production IGI
IGI: Inferred from genetic interaction
16831897 MGI
acts upstream of or within negative regulation of molecular function IDA
IDA: Inferred from direct assay
15030764 MGI
acts upstream of or within negative regulation of osteoblast differentiation IDA
IDA: Inferred from direct assay
15030764 MGI
involved in negative regulation of peroxisome proliferator activated receptor signaling pathway IDA
IDA: Inferred from direct assay
19345188 MGI
acts upstream of or within negative regulation of skeletal muscle tissue development IDA
IDA: Inferred from direct assay
7664846 MGI
involved in negative regulation of striated muscle tissue development IDA
IDA: Inferred from direct assay
9520323 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
7664846 MGI
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
16502419 MGI
acts upstream of or within negative regulation of tumor necrosis factor production IGI
IGI: Inferred from genetic interaction
16831897 MGI
acts upstream of or within neural tube closure IMP
IMP: Inferred from mutant phenotype
7729687 MGI
acts upstream of or within neuron migration IMP
IMP: Inferred from mutant phenotype
15162501 MGI
acts upstream of or within ossification IMP
IMP: Inferred from mutant phenotype
15030764 MGI
acts upstream of or within osteoblast differentiation IMP
IMP: Inferred from mutant phenotype
15030764 MGI
involved in positive regulation of cell motility IMP
IMP: Inferred from mutant phenotype
17332324 MGI
involved in positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation IDA
IDA: Inferred from direct assay
20804746 MGI
involved in positive regulation of epithelial to mesenchymal transition IMP
IMP: Inferred from mutant phenotype
17332324 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
24011070 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
17893140 MGI
acts upstream of or within stem cell differentiation IMP
IMP: Inferred from mutant phenotype
12142027 MGI
acts upstream of tumor necrosis factor production IGI
IGI: Inferred from genetic interaction
16831897 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
16100003 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

twist-related protein 1

  • Pluridigite

  • charlie chaplin

  • polydactyly EMS

  • twist gene homolog 1

  • twist homolog 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N2013 Aristolactam I 99.44% Unkown
HY-RS15281 TWIST1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-179340 Antiproliferative agent-74 Inducer / Unkown
HY-179452 KRAS G13D-IN-2 Inhibitor / Unkown
HY-182069 CDK9-IN-47 / Unkown
HY-RS20201 Twist1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26705 Twist1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Twist1 NCBI NCBI:7291