Tnfrsf4 - tumor necrosis factor receptor superfamily, member 4 Gene

Also Known as Ox40; ACT35; CD134; Ly-70; Txgp1; TXGP1L

Species: Mus musculus

Gene Type: protein coding

Gene ID: 22163

Summary

Enables tumor necrosis factor-activated receptor activity. Involved in negative regulation of apoptotic process; positive regulation of B cell proliferation; and regulation of gene expression. Acts upstream of or within several processes, including cellular defense response; negative regulation of cytokine production; and regulation of protein kinase activity. Located in external side of plasma membrane. Human ortholog(s) of this gene implicated in immunodeficiency 16. Orthologous to human TNFRSF4 (TNF Receptor Superfamily member 4). [provided by Alliance of Genome Resources, Apr 2022]

Tnfrsf4 Products (1)

mRNA	Protein	Name
NM_011659.2	NP_035789.1	tumor necrosis factor receptor superfamily member 4 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	7749983	MGI
enables tumor necrosis factor receptor activity	IPI IPI: Inferred from physical interaction	14635034	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within cellular defense response	IMP IMP: Inferred from mutant phenotype	10586044	MGI
acts upstream of or within inflammatory response	IMP IMP: Inferred from mutant phenotype	14730361	MGI
acts upstream of or within inflammatory response	IPI IPI: Inferred from physical interaction	14635034	MGI
involved in negative regulation of DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	7749983	MGI
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	7749983	MGI
involved in negative regulation of activation-induced cell death of T cells	IMP IMP: Inferred from mutant phenotype	11567634	MGI
acts upstream of or within negative regulation of cytokine production	IPI IPI: Inferred from physical interaction	14635034	MGI
involved in negative regulation of extrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	11567634	MGI
involved in positive regulation of B cell proliferation	IMP IMP: Inferred from mutant phenotype	7749983	MGI
involved in positive regulation of immunoglobulin production	IDA IDA: Inferred from direct assay	7749983	MGI
acts upstream of or within regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	14730361	MGI
acts upstream of or within regulation of protein kinase activity	IMP IMP: Inferred from mutant phenotype	14730361	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	16301745	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	10586044	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
tumor necrosis factor receptor superfamily member 4	OX40 antigen OX40L receptor tax-transcriptionally activated glycoprotein 1

Tnfrsf4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Tnfrsf4	P47741	Rps27a	Mus musculus	P62991	Anti Tag CoIP	21282629
Intra	Tnfrsf4	P47741	Traf2	Mus musculus	P39429	Anti Tag CoIP	21282629
Intra	Tnfrsf4	P47741	Traf2	Mus musculus	P39429	Y2H	9418902

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant Tnfrsf4 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72499	OX40/TNFRSF4 Protein, Mouse (HEK293, His)	P47741 (V20-P211)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P78190	OX40/TNFRSF4 Protein, Mouse (Biotinylated, HEK293, His-Avi)	P47741 (V20-P211)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P78334	OX40/TNFRSF4 Protein, Mouse (HEK293, His-Avi)	P47741 (V20-P211)	≥ 95%, as determined by Bis-Tris PAGE.

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P991614	IBI356	Inhibitor	/	Phase 2

Pre-clinical Phase

Inhibitory Antibodies (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P992132	Solaprubart	Inhibitor	99.59%	Unkown
HY-P992415	MSB013	Inhibitor	/	Unkown
HY-P992435	OX118	Inhibitor	/	Unkown
HY-P992368	HLX51	Agonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tnfrsf4	NCBI	NCBI:7293