country

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Ube3a - ubiquitin protein ligase E3A Gene

Also Known as Hpve6a; 4732496B02; 5830462N02Rik; A130086L21Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 22215

Summary

Enables transcription coactivator activity and ubiquitin protein Ligase activity. Involved in positive regulation of Golgi lumen acidification and regulation of circadian rhythm. Acts upstream of or within several processes, including cellular protein metabolic process; positive regulation of phosphatidylinositol 3-kinase signaling; and reproductive structure development. Located in cytosol and nucleus. Is expressed in central nervous system and retina. Used to study Angelman syndrome. Human ortholog(s) of this gene implicated in Angelman syndrome. Orthologous to human UBE3A (ubiquitin protein Ligase E3A). [provided by Alliance of Genome Resources, Apr 2022]

Ube3a Products (10)

mRNA	Protein	Name
NM_001033962.2	NP_001029134.1	ubiquitin-protein ligase E3A isoform 3
NM_001393666.1	NP_001380595.1	ubiquitin-protein ligase E3A isoform 2
NM_001393668.1	NP_001380597.1	ubiquitin-protein ligase E3A isoform 3
NM_001393669.1	NP_001380598.1	ubiquitin-protein ligase E3A isoform 4
NM_001393670.1	NP_001380599.1	ubiquitin-protein ligase E3A isoform 4
NM_001393671.1	NP_001380600.1	ubiquitin-protein ligase E3A isoform 4
NM_001393672.1	NP_001380601.1	ubiquitin-protein ligase E3A isoform 4
NM_001393973.1	NP_001380902.1	ubiquitin-protein ligase E3A isoform 2
NM_011668.3	NP_035798.2	ubiquitin-protein ligase E3A isoform 2
NM_173010.4	NP_766598.1	ubiquitin-protein ligase E3A isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	9182527	MGI
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	16254014	MGI
enables ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	9182527	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within androgen receptor signaling pathway	IPI IPI: Inferred from physical interaction	16254014	MGI
involved in modulation of chemical synaptic transmission	IDA IDA: Inferred from direct assay	26166566	MGI
involved in modulation of chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	26166566	MGI
involved in negative regulation of TORC1 signaling	IDA IDA: Inferred from direct assay	30020076	MGI
acts upstream of or within ovarian follicle development	IMP IMP: Inferred from mutant phenotype	11756548	MGI
involved in positive regulation of Golgi lumen acidification	IMP IMP: Inferred from mutant phenotype	23447592	MGI
acts upstream of or within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	16254014	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	16254014	MGI
acts upstream of or within prostate gland growth	IMP IMP: Inferred from mutant phenotype	11756548	MGI
involved in proteasome-mediated ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	30020076	MGI
acts upstream of or within protein ubiquitination	IDA IDA: Inferred from direct assay	9182527	MGI
involved in regulation of circadian rhythm	IMP IMP: Inferred from mutant phenotype	24728990	MGI
involved in regulation of synaptic plasticity	IDA IDA: Inferred from direct assay	30020076	MGI
acts upstream of or within sperm entry	IMP IMP: Inferred from mutant phenotype	11756548	MGI
acts upstream of or within ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	16254014	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cytosol	IDA IDA: Inferred from direct assay	9182527	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	26166566	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	26166566	MGI
located in nucleus	IDA IDA: Inferred from direct assay	9182527	MGI
is active in postsynaptic cytosol	IDA IDA: Inferred from direct assay	27339004	MGI
is active in synaptic vesicle	IDA IDA: Inferred from direct assay	27339004	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
ubiquitin-protein ligase E3A	E6-AP ubiquitin protein ligase HECT-type ubiquitin transferase E3A oncogenic protein-associated protein E6-AP ubiquitin conjugating enzyme E3A

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Phase
HY-177615	Apazunersen	Inhibitor	/	Phase 3
HY-177615A	Apazunersen sodium	Inhibitor	/	Phase 3
HY-177651	Obudanersen	Inhibitor	/	Phase 2
HY-177651A	Obudanersen sodium	Inhibitor	/	Phase 2
HY-148130	Rugonersen	Activator	98.50%	Phase 1
HY-148130A	Rugonersen sodium		97.47%	Phase 1

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-162683	(S)-PHA533533		98.27%	Unkown
HY-RS15368	UBE3A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20508	Ube3a Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27016	Ube3a Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ube3a	NCBI	NCBI:7337