Vegfc - vascular endothelial growth factor C Gene

Also Known as VEGF-C

Species: Mus musculus

Gene Type: protein coding
Gene ID: 22341

Summary

Enables vascular endothelial growth factor receptor 3 binding activity. Involved in several processes, including negative regulation of osteoblast differentiation; positive regulation of angiogenesis; and positive regulation of mesenchymal stem cell proliferation. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; positive regulation of lymphangiogenesis; and positive regulation of peptidyl-tyrosine phosphorylation. Located in extracellular space. Is expressed in several structures, including alimentary system mesentery; brain; cardiovascular system; embryo mesenchyme; and genitourinary system. Used to study hereditary lymphedema. Human ortholog(s) of this gene implicated in breast carcinoma and hereditary lymphedema ID. Orthologous to human VEGFC (vascular endothelial growth factor C). [provided by Alliance of Genome Resources, Apr 2022]

Vegfc Products (1)

mRNA Protein Name
NM_009506.2 NP_033532.1 vascular endothelial growth factor C precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25752543 MGI
enables vascular endothelial growth factor receptor 3 binding IPI
IPI: Inferred from physical interaction
9012504 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within animal organ morphogenesis IMP
IMP: Inferred from mutant phenotype
14634646 MGI
acts upstream of cell population proliferation IMP
IMP: Inferred from mutant phenotype
16462734 MGI
acts upstream of or within cellular response to leukemia inhibitory factor IEP
IEP: Inferred from expression pattern
20439489 MGI
acts upstream of glial cell proliferation IMP
IMP: Inferred from mutant phenotype
16462734 MGI
acts upstream of or within morphogenesis of embryonic epithelium IMP
IMP: Inferred from mutant phenotype
14634646 MGI
involved in negative regulation of osteoblast differentiation IDA
IDA: Inferred from direct assay
26934950 MGI
involved in positive regulation of angiogenesis IDA
IDA: Inferred from direct assay
24552833 MGI
involved in positive regulation of cell migration IDA
IDA: Inferred from direct assay
26934950 MGI
acts upstream of or within positive regulation of cell population proliferation IGI
IGI: Inferred from genetic interaction
9247316 MGI
acts upstream of or within positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
16462734 MGI
acts upstream of or within positive regulation of glial cell proliferation IMP
IMP: Inferred from mutant phenotype
16462734 MGI
acts upstream of or within positive regulation of lymphangiogenesis IDA
IDA: Inferred from direct assay
20133819 MGI
involved in positive regulation of lymphangiogenesis IDA
IDA: Inferred from direct assay
24552833 MGI
involved in positive regulation of mesenchymal stem cell proliferation IDA
IDA: Inferred from direct assay
26934950 MGI
involved in positive regulation of protein kinase activity IDA
IDA: Inferred from direct assay
26934950 MGI
acts upstream of or within vascular endothelial growth factor receptor signaling pathway IDA
IDA: Inferred from direct assay
9012504 MGI
involved in vascular endothelial growth factor receptor signaling pathway IDA
IDA: Inferred from direct assay
24552833 MGI
acts upstream of or within vascular endothelial growth factor receptor signaling pathway IGI
IGI: Inferred from genetic interaction
9247316 MGI
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
9247316 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

vascular endothelial growth factor C

  • VRP

  • flt4 ligand

  • flt4-L

  • vascular endothelial growth factor-related protein

Recombinant Vegfc Proteins

Cat. No. Product Name Accession Purity
HY-P74474 VEGF-C Protein, Mouse/Rat (HEK293, His) P97953-1/NP_033532.1/O35757 (A108-R223) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P74475 VEGF-C Protein, Mouse/Rat (HEK293, Fc) P97953 (A108-R223)/O35757(A108-R223) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-P3369 Gersizangitide 97.16% Phase 2
Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Phase
HY-P99830 Conbercept Inhibitor 98.42% Phase 4
HY-P990675 VGX-100 Inhibitor 99.54% Phase 1

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N2187 Deoxyshikonin 99.96% Unkown
HY-P11474 FZ1 peptide 99.92% Unkown
HY-RS15637 VEGFC Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174507 Human VEGFD mRNA / Unkown
HY-174508 Human VEGFC mRNA / Unkown
HY-RS16674 Vegfc Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23109 Vegfc Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P9920A Ramucirumab (anti-VEGFR) Antagonist 99.9% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Vegfc NCBI NCBI:7424