Dmrt2 - doublesex and mab-3 related transcription factor 2 Gene

Also Known as Terra

Species: Mus musculus

Gene Type: protein coding
Gene ID: 226049

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within embryonic skeletal system development; positive regulation of myotome development; and regulation of somitogenesis. Predicted to be active in nucleus. Is expressed in several structures, including embryo mesenchyme; genitourinary system; limb; oral epithelium; and thymus primordium. Orthologous to human DMRT2 (doublesex and mab-3 related transcription factor 2). [provided by Alliance of Genome Resources, Apr 2022]

Dmrt2 Products (1)

mRNA Protein Name
NM_145831.3 NP_665830.1 doublesex- and mab-3-related transcription factor 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific IMP
IMP: Inferred from mutant phenotype
17974128 MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
17605809 MGI
enables identical protein binding IPI
IPI: Inferred from physical interaction
17605809 MGI
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
17605809 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within embryonic skeletal system development IMP
IMP: Inferred from mutant phenotype
16387292 MGI
NOT acts upstream of or within left/right pattern formation IMP
IMP: Inferred from mutant phenotype
21203428 MGI
acts upstream of myotome development IMP
IMP: Inferred from mutant phenotype
16387292 MGI
acts upstream of or within positive regulation of myotome development IMP
IMP: Inferred from mutant phenotype
16387292 MGI
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
17974128 MGI
acts upstream of or within regulation of somitogenesis IGI
IGI: Inferred from genetic interaction
17974128 MGI
acts upstream of or within regulation of somitogenesis IMP
IMP: Inferred from mutant phenotype
17974128 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

doublesex- and mab-3-related transcription factor 2

  • doublesex-like 2 protein

  • terra homolog

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03829 DMRT2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21557 Dmrt2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28075 Dmrt2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dmrt2 NCBI NCBI:10655