Smyd2 - SET and MYND domain containing 2 Gene

Also Known as KMT3C; Zmynd14; 4930402C15; 1110020E07Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 226830

About Smyd2

Chromosome 1: 189,612,689-189,654,560 reverse strand.GRCm39:CM000994.3

This gene has 4 transcripts (splice variants), 229 orthologues, 5 paralogues and is associated with 6 phenotypes. Ubiquitous expression in ovary adult (RPKM 31.3), heart adult (RPKM 3.2) and 28 other tissues.

Summary

Enables RNA polymerase II complex binding activity and Histone Methyltransferase activity (H3-K36 specific). Involved in negative regulation of cell population proliferation and peptidyl-lysine dimethylation. Acts upstream of or within histone methylation. Located in cytosol and nucleus. Is expressed in several structures, including heart; hemolymphoid system gland; nasal cavity epithelium; nervous system; and retina. Orthologous to human SMYD2 (SET and MYND domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]

Smyd2 Products (1)

mRNA Protein Name
NM_026796.2 NP_081072.1 N-lysine methyltransferase SMYD2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables RNA polymerase II complex binding IDA
IDA: Inferred from direct assay
20305823 MGI
enables histone H3K36 methyltransferase activity IDA
IDA: Inferred from direct assay
16805913 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
16805913 MGI
Biological Process GO Annotation Evidence References Source
involved in negative regulation of cell population proliferation IDA
IDA: Inferred from direct assay
16805913 MGI
involved in peptidyl-lysine dimethylation IDA
IDA: Inferred from direct assay
16805913 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
16805913 MGI
located in cytosol IDA
IDA: Inferred from direct assay
20305823 MGI
located in nucleus IDA
IDA: Inferred from direct assay
16805913 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Smyd2 Protein Structure

SET_SMYD2

SET_SMYD2: cd19202 (6 - 268)

zf-MYND

zf-MYND: pfam01753 (51 - 89)

TPR_10

TPR_10: pfam13374 (387 - 421)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 433 a.a.
Protein Preferred Names Protein Names

N-lysine methyltransferase SMYD2

  • SET and MYND domain-containing protein 2

  • histone methyltransferase SMYD2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-19313 LLY-507 Inhibitor 99.09% Unkown
HY-15226 AZ505 Inhibitor 99.99% Unkown
HY-141877 MS4322 Degrader 99.14% Unkown
HY-19546 BAY-598 Inhibitor 99.33% Unkown
HY-15226A AZ505 ditrifluoroacetate Inhibitor 99.89% Unkown
HY-134828 AZ506 Inhibitor 99.74% Unkown
HY-141877B MS4322 (isomer) 99.87% Unkown
HY-19563 A-893 Inhibitor / Unkown
HY-111367 MS2734 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Smyd2 NCBI NCBI:56950