RASA3 - RAS p21 protein activator 3 Gene

Also Known as GAPIII; GAP1IP4BP

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 22821

About RASA3

Cytogenetic location: 13q34 Genomic coordinates (GRCh38): 13:113,977,783-114,132,623 (from NCBI)

This gene has 2 transcripts (splice variants), 1 gene allele, 216 orthologues and 10 paralogues. Ubiquitous expression in fat (RPKM 14.2), lymph node (RPKM 12.1) and 25 other tissues.

Summary

This gene encodes a protein that binds inositol 1,3,4,5-tetrakisphosphate and stimulates the GTPase activity of Ras p21. This protein functions as a negative regulator of the Ras signalling pathway. It is localized to the cell membrane via a pleckstrin homology (PH) domain in the C-terminal region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

RASA3 Products (3)

mRNA Protein Name
NM_001320821.2 NP_001307750.1 ras GTPase-activating protein 3 isoform 2
NM_001320822.2 NP_001307751.1 ras GTPase-activating protein 3 isoform 3
NM_007368.4 NP_031394.2 ras GTPase-activating protein 3 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables calcium channel regulator activity IDA
IDA: Inferred from direct assay
10828023 GOA
Biological Process GO Annotation Evidence References Source
involved in platelet activation IDA
IDA: Inferred from direct assay
10828023 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasmic side of plasma membrane IDA
IDA: Inferred from direct assay
10828023 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RASA3 Protein Structure

C2

C2: C2 domain (15 - 95)

C2

C2: C2 domain (149 - 246)

RasGAP

RasGAP: GTPase-activator protein for Ras-like GTPase (351 - 523)

PH

PH: PH domain (578 - 675)

BTK

BTK: BTK motif (685 - 714)

  • 0
  • 200
  • 400
  • 600
  • 834 a.a.
Protein Preferred Names Protein Names

ras GTPase-activating protein 3

  • GTPase activating protein III

Related Diseases

Diseases Alias
Paralytic Poliomyelitis

  • Poliomyelitis, Paralytic
Poliomyelitis

  • Polio

  • Infantile Paralysis
Acquired Thrombocytopenia

  • Secondary Thrombocytopenia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11680 RASA3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21719 Rasa3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28237 Rasa3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus RASA3 VGNC VGNC:64496
Macaca mulatta RASA3 VGNC VGNC:76513
Canis familiaris RASA3 VGNC VGNC:45361
Rattus norvegicus RASA3 RGD RGD:69365
Bos taurus RASA3 VGNC VGNC:33737
Mus musculus RASA3 MGD MGI:1197013
Others RASA3 NCBI