Gba2 - glucosidase beta 2 Gene

Also Known as F630034E04

Species: Mus musculus

Gene Type: protein coding
Gene ID: 230101

Summary

Enables glucosylceramidase activity; glucosyltransferase activity; and steryl-beta-glucosidase activity. Involved in several processes, including glucosylceramide catabolic process; lipid glycosylation; and regulation of protein polymerization. Located in cytosol. Is extrinsic component of Golgi membrane and extrinsic component of endoplasmic reticulum membrane. Is expressed in several structures, including central nervous system; dorsal root ganglion; liver; lung; and neural retina. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 46. Orthologous to human GBA2 (glucosylceramidase beta 2). [provided by Alliance of Genome Resources, Apr 2022]

Gba2 Products (1)

mRNA Protein Name
NM_172692.3 NP_766280.2 non-lysosomal glucosylceramidase

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables beta-glucosidase activity IDA
IDA: Inferred from direct assay
22659419 MGI
enables beta-glucosidase activity IMP
IMP: Inferred from mutant phenotype
22659419 MGI
enables glucosylceramidase activity IDA
IDA: Inferred from direct assay
17080196 MGI
enables glucosylceramidase activity IMP
IMP: Inferred from mutant phenotype
22659419 MGI
enables glucosyltransferase activity IDA
IDA: Inferred from direct assay
17080196 MGI
enables steryl-beta-glucosidase activity IDA
IDA: Inferred from direct assay
26724485 MGI
Biological Process GO Annotation Evidence References Source
NOT involved in bile acid metabolic process IMP
IMP: Inferred from mutant phenotype
17080196 MGI
involved in cholesterol metabolic process IMP
IMP: Inferred from mutant phenotype
26724485 MGI
involved in glucosylceramide catabolic process IDA
IDA: Inferred from direct assay
23250757 MGI
involved in glucosylceramide catabolic process IMP
IMP: Inferred from mutant phenotype
17080196 MGI
involved in lipid glycosylation IDA
IDA: Inferred from direct assay
26724485 MGI
involved in regulation of actin filament polymerization IMP
IMP: Inferred from mutant phenotype
25803043 MGI
involved in regulation of membrane lipid distribution IMP
IMP: Inferred from mutant phenotype
25803043 MGI
involved in regulation of microtubule polymerization IMP
IMP: Inferred from mutant phenotype
25803043 MGI
Cellular Component GO Annotation Evidence References Source
located in Golgi membrane IDA
IDA: Inferred from direct assay
23250757 MGI
located in cytosol IDA
IDA: Inferred from direct assay
23250757 MGI
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
23250757 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

non-lysosomal glucosylceramidase

  • NLGase

  • beta-glucocerebrosidase 2

  • beta-glucosidase 2

  • bile acid beta-glucosidase GBA2

  • bile acid glucosyl transferase GBA2

  • cholesterol glucosyltransferase GBA2

  • cholesteryl-beta-glucosidase GBA2

  • glucosidase, beta (bile acid) 2

  • glucosylceramidase 2

  • no

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-129411 Sinbaglustat 99.83% Unkown
HY-178202 5-C-phenethyl-DNJ Inhibitor / Unkown
HY-RS05302 GBA2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18361 Gba2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24840 Gba2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gba2 NCBI NCBI:57704