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Npr2 - natriuretic peptide receptor 2 Gene

Also Known as cn; pwe; GC-B; GC-B2; GC-B3; mNPR-B

Species: Mus musculus

Gene Type: protein coding

Gene ID: 230103

Summary

Enables Guanylate Cyclase activity; identical protein binding activity; and natriuretic peptide receptor activity. Acts upstream of or within several processes, including bone development; negative regulation of meiotic cell cycle; and negative regulation of oocyte maturation. Predicted to be integral component of plasma membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; sensory organ; and skeleton. Used to study achondroplasia; acromesomelic dysplasia, Maroteaux type; and bone development disease. Human ortholog(s) of this gene implicated in Miura type epiphyseal chondrodysplasia; acromesomelic dysplasia, Maroteaux type; and essential hypertension. Orthologous to human NPR2 (natriuretic peptide receptor 2). [provided by Alliance of Genome Resources, Apr 2022]

Npr2 Products (4)

mRNA	Protein	Name
NM_001355466.1	NP_001342395.1	atrial natriuretic peptide receptor 2 isoform 2 precursor
NM_173788.4	NP_776149.1	atrial natriuretic peptide receptor 2 isoform 1 precursor
NM_001355466.1	NP_001342395.1	atrial natriuretic peptide receptor 2 isoform 2 precursor
NM_173788.4	NP_776149.1	atrial natriuretic peptide receptor 2 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables guanylate cyclase activity	IDA IDA: Inferred from direct assay	14514678	MGI
enables identical protein binding	IPI IPI: Inferred from physical interaction	14514678	MGI
enables natriuretic peptide receptor activity	IDA IDA: Inferred from direct assay	14514678	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in MAPK cascade	IMP IMP: Inferred from mutant phenotype	23065701	MGI
involved in activation of meiosis involved in egg activation	IMP IMP: Inferred from mutant phenotype	22987720	MGI
involved in axonogenesis	IMP IMP: Inferred from mutant phenotype	17954614	MGI
involved in axonogenesis involved in innervation	IMP IMP: Inferred from mutant phenotype	25473838	MGI
involved in blood circulation	IMP IMP: Inferred from mutant phenotype	32901096	MGI
involved in blood vessel development	IMP IMP: Inferred from mutant phenotype	32901096	MGI
involved in blood vessel remodeling	IMP IMP: Inferred from mutant phenotype	32394795	MGI
acts upstream of or within bone development	IMP IMP: Inferred from mutant phenotype	624676	MGI
involved in bone growth	IMP IMP: Inferred from mutant phenotype	23065701	MGI
involved in c-di-GMP signaling	IMP IMP: Inferred from mutant phenotype	20616347	MGI
involved in cGMP metabolic process	IMP IMP: Inferred from mutant phenotype	15722353	MGI
involved in cartilage development	IMP IMP: Inferred from mutant phenotype	15722353	MGI
involved in cellular response to cGMP	IMP IMP: Inferred from mutant phenotype	26522847	MGI
involved in cellular response to peptide	IMP IMP: Inferred from mutant phenotype	28054671	MGI
involved in chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	17954614	MGI
involved in chondrocyte differentiation	IMP IMP: Inferred from mutant phenotype	17728275	MGI
involved in chondrocyte proliferation	IMP IMP: Inferred from mutant phenotype	17728275	MGI
involved in chromosome organization	IMP IMP: Inferred from mutant phenotype	22696190	MGI
involved in collateral sprouting	IMP IMP: Inferred from mutant phenotype	17954614	MGI
involved in cumulus cell differentiation	IMP IMP: Inferred from mutant phenotype	22696190	MGI
involved in digestive tract development	IMP IMP: Inferred from mutant phenotype	32901096	MGI
involved in digestive tract morphogenesis	IMP IMP: Inferred from mutant phenotype	20616347	MGI
involved in endochondral ossification	IMP IMP: Inferred from mutant phenotype	15572448	MGI
involved in epidermal growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	22987720	MGI
involved in execution phase of apoptosis	IMP IMP: Inferred from mutant phenotype	25012822	MGI
involved in female genitalia development	IMP IMP: Inferred from mutant phenotype	15572448	MGI
involved in gastric emptying	IMP IMP: Inferred from mutant phenotype	23127564	MGI
involved in genitalia morphogenesis	IMP IMP: Inferred from mutant phenotype	25012822	MGI
involved in germ cell development	IMP IMP: Inferred from mutant phenotype	25012822	MGI
involved in growth plate cartilage development	IMP IMP: Inferred from mutant phenotype	17728275	MGI
involved in limb development	IMP IMP: Inferred from mutant phenotype	15572448	MGI
involved in limb morphogenesis	IMP IMP: Inferred from mutant phenotype	17728275	MGI
involved in lymph vessel development	IMP IMP: Inferred from mutant phenotype	32901096	MGI
acts upstream of meiotic cell cycle	IMP IMP: Inferred from mutant phenotype	20947764	MGI
involved in meiotic cell cycle process involved in oocyte maturation	IMP IMP: Inferred from mutant phenotype	22696190	MGI
involved in multicellular organism growth	IMP IMP: Inferred from mutant phenotype	15572448	MGI
involved in multicellular organismal reproductive process	IMP IMP: Inferred from mutant phenotype	23065701	MGI
acts upstream of or within negative regulation of meiotic cell cycle	IMP IMP: Inferred from mutant phenotype	20947764	MGI
acts upstream of or within negative regulation of oocyte maturation	IMP IMP: Inferred from mutant phenotype	20947764	MGI
involved in nerve development	IMP IMP: Inferred from mutant phenotype	32901096	MGI
involved in neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	29501420	MGI
involved in neuronal action potential	IMP IMP: Inferred from mutant phenotype	25473838	MGI
involved in oocyte development	IMP IMP: Inferred from mutant phenotype	22696190	MGI
involved in ovarian follicle development	IMP IMP: Inferred from mutant phenotype	22696190	MGI
involved in post-anal tail morphogenesis	IMP IMP: Inferred from mutant phenotype	17728275	MGI
involved in renal system development	IMP IMP: Inferred from mutant phenotype	31220449	MGI
acts upstream of or within reproductive process	IMP IMP: Inferred from mutant phenotype	20947764	MGI
involved in response to fibroblast growth factor	IMP IMP: Inferred from mutant phenotype	29199951	MGI
involved in response to hormone	IMP IMP: Inferred from mutant phenotype	20616347	MGI
involved in response to luteinizing hormone	IMP IMP: Inferred from mutant phenotype	26522847	MGI
involved in response to salt	IMP IMP: Inferred from mutant phenotype	31220449	MGI
involved in response to wounding	IMP IMP: Inferred from mutant phenotype	31220449	MGI
involved in sensory perception of sound	IMP IMP: Inferred from mutant phenotype	30275816	MGI
involved in single fertilization	IMP IMP: Inferred from mutant phenotype	22696190	MGI
involved in smooth muscle tissue development	IMP IMP: Inferred from mutant phenotype	32901096	MGI
involved in spermatogenesis	IMP IMP: Inferred from mutant phenotype	25012822	MGI
involved in startle response	IMP IMP: Inferred from mutant phenotype	30275816	MGI
involved in vacuole organization	IMP IMP: Inferred from mutant phenotype	25012822	MGI
involved in vascular wound healing	IMP IMP: Inferred from mutant phenotype	32394795	MGI
involved in vasculogenesis	IMP IMP: Inferred from mutant phenotype	32394795	MGI
involved in vestibulocochlear nerve development	IMP IMP: Inferred from mutant phenotype	30275816	MGI
involved in vestibulocochlear nerve maturation	IMP IMP: Inferred from mutant phenotype	25473838	MGI
involved in white fat cell differentiation	IMP IMP: Inferred from mutant phenotype	32901096	MGI

Cellular Component GO Annotation	Evidence	References	Source
is active in cilium	IDA IDA: Inferred from direct assay	28054671	MGI
is active in cytoplasm	IDA IDA: Inferred from direct assay	23127564	MGI
is active in neuron projection	IDA IDA: Inferred from direct assay	23127564	MGI
is active in nucleus	IDA IDA: Inferred from direct assay	23127564	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
atrial natriuretic peptide receptor 2	ANP-B ANPR-B NPR-B Nppb receptor atrial natriuretic peptide receptor type B guanylate cyclase B guanylyl cyclase-B natriuretic peptide receptor B type

Related Agents

Approval
Pre-clinical Phase

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P3503A	Vosoritide acetate	Inhibitor	99.96%	Unkown

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09498	NPR2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS09500	NPRL2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21394	Npr2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27913	Npr2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Npr2	NCBI	NCBI:4882