MON2 - MON2 homolog, regulator of endosome-to-Golgi trafficking Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23041

About MON2

Cytogenetic location: 12q14.1 Genomic coordinates (GRCh38): 12:62,466,826-62,600,476 (from NCBI)

This gene has 14 transcripts (splice variants), 209 orthologues and 15 paralogues. Ubiquitous expression in thyroid (RPKM 6.3), ovary (RPKM 5.3) and 25 other tissues.

Summary

Predicted to be involved in Golgi to endosome transport. Located in early endosome membrane. [provided by Alliance of Genome Resources, Apr 2022]

MON2 Products (5)

mRNA Protein Name
NM_001278469.3 NP_001265398.1 protein MON2 homolog isoform 2
NM_001278470.2 NP_001265399.1 protein MON2 homolog isoform 3
NM_001278471.2 NP_001265400.1 protein MON2 homolog isoform 4
NM_001278472.2 NP_001265401.1 protein MON2 homolog isoform 5
NM_015026.3 NP_055841.2 protein MON2 homolog isoform 1

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
18418388 GOA
Cellular Component GO Annotation Evidence References Source
located in early endosome membrane IDA
IDA: Inferred from direct assay
30213940 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MON2 Protein Structure

Sec7_N

Sec7_N: Guanine nucleotide exchange factor in Golgi transport N-terminal (211 - 286)

Sec7_N

Sec7_N: Guanine nucleotide exchange factor in Golgi transport N-terminal (306 - 386)

DUF1981

DUF1981: Domain of unknown function (DUF1981) (849 - 933)

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  • 1500
  • 1718 a.a.
Protein Preferred Names Protein Names

protein MON2 homolog

  • MON2 regulator of endosome-to-Golgi trafficking

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08588 MON2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris MON2 VGNC VGNC:43315
Bos taurus MON2 VGNC VGNC:31553
Macaca mulatta MON2 VGNC VGNC:74854
Felis catus MON2 VGNC VGNC:63556
Mus musculus MON2 MGD MGI:1914324
Rattus norvegicus MON2 RGD RGD:1308808
Others MON2 NCBI