Usp1 - ubiquitin specific peptidase 1 Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 230484

Summary

This gene encodes a member of the ubiquitin-specific peptidase family. The encoded protein acts as a catalytic subunit in a heterodimeric deubiquitinating enzyme complex that deubiquitinates Fanconi anemia, complementation group D2, and plays a role in homologous recombination-mediated DNA repair. Disruption of this gene is associated with a Fanconi anemia-like phenotype and genomic instability. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 3, 12, and 15. [provided by RefSeq, Aug 2014]

Usp1 Products (6)

mRNA Protein Name
NM_001301414.1 NP_001288343.1 ubiquitin carboxyl-terminal hydrolase 1 isoform 1
NM_001356424.1 NP_001343353.1 ubiquitin carboxyl-terminal hydrolase 1 isoform 2
NM_146144.4 NP_666256.2 ubiquitin carboxyl-terminal hydrolase 1 isoform 1
NM_001301414.1 NP_001288343.1 ubiquitin carboxyl-terminal hydrolase 1 isoform 1
NM_001356424.1 NP_001343353.1 ubiquitin carboxyl-terminal hydrolase 1 isoform 2
NM_146144.4 NP_666256.2 ubiquitin carboxyl-terminal hydrolase 1 isoform 1

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
acts upstream of or within skeletal system development IMP
IMP: Inferred from mutant phenotype
21925315 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ubiquitin carboxyl-terminal hydrolase 1

  • deubiquitinating enzyme 1

  • ubiquitin specific protease 1

  • ubiquitin thioesterase 1

  • ubiquitin thiolesterase 1

  • ubiquitin-specific-processing protease 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (11)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-145471 KSQ-4279 Inhibitor 99.96% Unkown
HY-145471A KSQ-4279 gentisate Inhibitor 99.75% Unkown
HY-148099 USP1-IN-2 Inhibitor 99.76% Unkown
HY-181702 USP1-IN-16 Inhibitor / Unkown
HY-176704 USP1-IN-13 Inhibitor / Unkown
HY-183581 USP1-IN-18 Inhibitor / Unkown
HY-180216 USP1-IN-15 Inhibitor / Unkown
HY-176703 USP1-IN-12 Inhibitor / Unkown
HY-161878 USP1-IN-10 Inhibitor / Unkown
HY-153731 USP1-IN-4 Inhibitor / Unkown
HY-179292 USP1-IN-14 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Usp1 NCBI NCBI:7398