USP1-IN-19
USP1-IN-19 is a USP1 inhibitor with an IC50 of 0-50 nM in the USP1-UAF1 deubiquitination assay. USP1-IN-19 exhibits dose-dependent antitumor effects against non-small cell lung cancer and breast cancer. USP1-IN-19 can be used for cancer research.
For research use only. We do not sell to patients.
- CAS No.: 3068739-67-0
- Formula: C33H34F3N7O3
- Molecular Weight:633.66
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
USP1 0-50 nM (IC50) |
In Vitro
USP1-IN-19 (Compound 30) shows antiproliferative effects in MDA-MB-436 cells and NCI-H1792 cells, with IC50 values of 0-50 nM and 50-1000 nM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Mice transplanted with MDA-MB-436 cells[1]
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Dosage:10, 25, 50 mg/kg
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Administration:once or twice daily
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Result:Showed a TGI of 99% (50 mg/kg, QD).
Showed a TGI of 82% (25 mg/kg, QD).
Showed a TGI of 106% (25 mg/kg, BID).
Showed a TGI of 88% (10 mg/kg, BID).
Chemical Information
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CAS No. 3068739-67-0
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Molecular Weight 633.66
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Formula C33H34F3N7O3
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SMILES
COC1=NC=NC(C2CC2)=C1C3=NC(NCC4=CC=C(C5=C(C6CCN(C(C)=O)CC6)C=CC(C(F)(F)F)=N5)C=C4)=C(OC)C=N3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
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Breast Cancer Modeling
Breast cancer is a heterogeneous cancer, and it has been distinguished into four subtypes: luminal A, luminal B, HER2-positive and basal-like. Molecular mutations, epigenetic alterations, hormone exposure and immune microenvironment are related to the progression of breast cancer.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
USP1-IN-19 Related Classifications
HY-187468 Related Classifications
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