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Art. -Nr.: HY-187468

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USP1-IN-19

USP1-IN-19 is a USP1 inhibitor with an IC₅₀ of 0-50 nM in the USP1-UAF1 deubiquitination assay. USP1-IN-19 exhibits dose-dependent antitumor effects against non-small cell lung cancer and breast cancer. USP1-IN-19 can be used for cancer research.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 3068739-67-0
Formel: C₃₃H₃₄F₃N₇O₃
Molecular Weight:633.66

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

USP1-IN-19 Chemical Structure

CAS. Nr.: 3068739-67-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

^[1]

USP1

0-50 nM (IC₅₀)

Alle Deubiquitinase Isoform-spezifische Produkte anzeigen :

In Vitro

Anti-cancer

USP1-IN-19 (Compound 30) shows antiproliferative effects in MDA-MB-436 cells and NCI-H1792 cells, with IC₅₀ values of 0-50 nM and 50-1000 nM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Anti-cancer

USP1-IN-19 (10-50 mg/kg; once or twice daily) shows dose-dependent antitumor effects in mice transplanted with MDA-MB-436 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Mice transplanted with MDA-MB-436 cells^[1]
Dosage:

10, 25, 50 mg/kg
Administration:

once or twice daily
Result:

Showed a TGI of 99% (50 mg/kg, QD).
Showed a TGI of 82% (25 mg/kg, QD).
Showed a TGI of 106% (25 mg/kg, BID).
Showed a TGI of 88% (10 mg/kg, BID).

Related Protocols :

Breast Cancer Modeling

Chemical Information

CAS. Nr. 3068739-67-0
Molecular Weight 633.66
Formel C₃₃H₃₄F₃N₇O₃
SMILES

COC1=NC=NC(C2CC2)=C1C3=NC(NCC4=CC=C(C5=C(C6CCN(C(C)=O)CC6)C=CC(C(F)(F)F)=N5)C=C4)=C(OC)C=N3
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Wang, et al. Pyrimidine compounds and their use as usp1 inhibitors. WO2025015905A1. WIPO (PCT). 2024-02-08.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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