FMO2 - flavin containing dimethylaniline monoxygenase 2 Gene

Also Known as FMO1B1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2327

About FMO2

Cytogenetic location: 1q24.3 Genomic coordinates (GRCh38): 1:171,185,208-171,212,686 (from NCBI)

This gene has 7 transcripts (splice variants), 136 orthologues and 5 paralogues. Biased expression in fat (RPKM 59.7), lung (RPKM 58.7) and 8 other tissues.

Summary

This gene encodes a flavin-containing monooxygenase family member. It is an NADPH-dependent enzyme that catalyzes the N-oxidation of some primary alkylamines through an N-hydroxylamine intermediate. However, some human populations contain an allele (FMO2*2A) with a premature stop codon, resulting in a protein that is C-terminally-truncated, has no catalytic activity, and is likely degraded rapidly. This gene is found in a cluster with Other related family members on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]

FMO2 Products (3)

mRNA	Protein	Name
NM_001301347.2	NP_001288276.1	flavin-containing monooxygenase 2 isoform b
NM_001365900.1	NP_001352829.1	flavin-containing monooxygenase 2 isoform c
NM_001460.5	NP_001451.2	flavin-containing monooxygenase 2 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables N,N-dimethylaniline monooxygenase activity	IDA IDA: Inferred from direct assay	11744609	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in NADP metabolic process	IDA IDA: Inferred from direct assay	11744609	GOA
involved in NADPH oxidation	IDA IDA: Inferred from direct assay	9804831	GOA
involved in organic acid metabolic process	IDA IDA: Inferred from direct assay	11744609	GOA
involved in toxin metabolic process	IDA IDA: Inferred from direct assay	11744609	GOA
involved in xenobiotic metabolic process	IDA IDA: Inferred from direct assay	11744609	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in membrane	IDA IDA: Inferred from direct assay	9804831	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FMO2 Protein Structure

FMO-like

0
100
200
300
400
471 a.a.

Protein Preferred Names	Protein Names
flavin-containing monooxygenase 2	FMO, pulmonary

Related Diseases

Diseases	Alias
Trimethylaminuria	TMAU Fish-Odor Syndrome Fish Malodor Syndrome Fish Odor Syndrome Stale Fish Syndrome Tmauria Severe Primary Trimethylaminuria Mesh D008661 Fish Odour Syndrome
Prader-Willi Syndrome	Prader-Labhart-Willi Syndrome PWS Willi-Prader Syndrome Prader-Willi Syndrome Due To Translocation Prader-Willi Syndrome Due To Imprinting Mutation Prader-Willi Syndrome Due To Maternal Uniparental Disomy Of Chromosome 15 Prader Willi Syndrome Upd(15)Mat

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05006	FMO2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS05008	FMO4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	FMO2	VGNC	VGNC:72683
Felis catus	FMO2	VGNC	VGNC:62308
Bos taurus	FMO2	VGNC	VGNC:29050
Canis familiaris	FMO2	VGNC	VGNC:40917
Rattus norvegicus	FMO2	RGD	RGD:628600
Mus musculus	FMO2	MGD	MGI:1916776
Others	FMO2	NCBI