Scap - SREBF chaperone Gene

Also Known as mKIAA0199; 9530044G19

Species: Mus musculus

Gene Type: protein coding
Gene ID: 235623

Summary

Predicted to enable Cholesterol binding activity. Acts upstream of or within several processes, including Cholesterol metabolic process; regulation of lipid biosynthetic process; and response to Insulin. Located in endoplasmic reticulum membrane. Is expressed in 1st branchial arch maxillary component; brain; heart; liver; and sensory organ. Orthologous to human SCAP (SREBF chaperone). [provided by Alliance of Genome Resources, Apr 2022]

Scap Products (3)

mRNA Protein Name
NM_001001144.3 NP_001001144.2 sterol regulatory element-binding protein cleavage-activating protein
NM_001103162.2 NP_001096632.1 sterol regulatory element-binding protein cleavage-activating protein
NM_001410582.1 NP_001397511.1 sterol regulatory element-binding protein cleavage-activating protein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
12242332 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cellular lipid metabolic process IMP
IMP: Inferred from mutant phenotype
22337502 MGI
acts upstream of or within cholesterol metabolic process IDA
IDA: Inferred from direct assay
11358865 MGI
acts upstream of or within immune response IMP
IMP: Inferred from mutant phenotype
22337502 MGI
acts upstream of or within regulation of cholesterol biosynthetic process IMP
IMP: Inferred from mutant phenotype
16054043 MGI
acts upstream of or within regulation of fatty acid biosynthetic process IMP
IMP: Inferred from mutant phenotype
16054043 MGI
acts upstream of or within regulation of fatty acid metabolic process IDA
IDA: Inferred from direct assay
11358865 MGI
acts upstream of or within response to hypoxia IMP
IMP: Inferred from mutant phenotype
17666524 MGI
acts upstream of or within response to insulin IMP
IMP: Inferred from mutant phenotype
16054043 MGI
Cellular Component GO Annotation Evidence References Source
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
12242332 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

sterol regulatory element-binding protein cleavage-activating protein

  • SREBP cleavage activating protein

  • Sreb cleavage-activating protein

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (12)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-14452 Fatostatin Inhibitor 99.85% Unkown
HY-N0288 Lycorine 99.98% Unkown
HY-14452A Fatostatin hydrobromide Inhibitor 99.52% Unkown
HY-N0288R Lycorine (Standard) 99.54% Unkown
HY-16244 GW-300 Ligand / Unkown
HY-RS12484 SCAP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12823 SH2D2A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-149657 SREBP/SCAP-IN-1 Inhibitor / Unkown
HY-149658 SREBP/SCAP-IN-2 Inhibitor / Unkown
HY-RS17143 Scap Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23590 Scap Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W129441 N-Acetyl-4-S-cysteaminylphenol / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Scap NCBI NCBI:22937