Adamts5 - a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2) Gene

Also Known as ADMP-2; ASMP-2; ADAMTS1; ADAM-TS5; ADAMTS11; 9530092O11Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 23794

Summary

This gene encodes a member of "a disintegrin and metalloproteinase with thrombospondin motifs" (ADAMTS) family of multi-domain matrix-associated metalloendopeptidases that have diverse roles in tissue morphogenesis and pathophysiological remodeling, in inflammation and in vascular biology. The encoded preproprotein undergoes proteolytic processing to generate an active, zinc-dependent aggrecanase enzyme. Mice lacking the encoded protein are protected from surgery-induced osteoarthritis and antigen-induced arthritis. [provided by RefSeq, May 2016]

Adamts5 Products (1)

mRNA Protein Name
NM_011782.2 NP_035912.2 A disintegrin and metalloproteinase with thrombospondin motifs 5 preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables endopeptidase activity IMP
IMP: Inferred from mutant phenotype
23233679 MGI
enables extracellular matrix binding IDA
IDA: Inferred from direct assay
24220035 MGI
enables heparin binding IDA
IDA: Inferred from direct assay
24220035 MGI
enables metallopeptidase activity IDA
IDA: Inferred from direct assay
33719441 MGI
Biological Process GO Annotation Evidence References Source
involved in aortic valve morphogenesis IMP
IMP: Inferred from mutant phenotype
23531444 MGI
acts upstream of or within defense response to bacterium IGI
IGI: Inferred from genetic interaction
23684986 MGI
involved in endocardial cushion morphogenesis IGI
IGI: Inferred from genetic interaction
23531444 MGI
involved in extracellular matrix disassembly IMP
IMP: Inferred from mutant phenotype
23233679 MGI
involved in myoblast fusion IMP
IMP: Inferred from mutant phenotype
23233679 MGI
involved in negative regulation of cold-induced thermogenesis IMP
IMP: Inferred from mutant phenotype
28702327 MGI
involved in pulmonary valve morphogenesis IMP
IMP: Inferred from mutant phenotype
23531444 MGI
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
24220035 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

A disintegrin and metalloproteinase with thrombospondin motifs 5

  • aggrecanase-2

  • implantin

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-12270 T-5224 Inhibitor 99.59% Phase 2
HY-137430 Aldumastat Inhibitor 99.36% Phase 2
HY-160822 AGG-523 Inhibitor 99.32% Phase 1

Pre-clinical Phase

Bioactive Molecules (12)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-114996 ADAMTS-5 Inhibitor Inhibitor 99.59% Unkown
HY-P10398 5-FAM-TEGEARGSVILLK(5-TAMRA)K-NH2 TFA 91.94% Unkown
HY-145061 ADAMTS-5-IN-3 Inhibitor 98.89% Unkown
HY-P5419A WAAG-3R TFA 99.75% Unkown
HY-135710 ADAMTS-5-IN-2 Inhibitor 98.73% Unkown
HY-12270S T-5224-d8 / Unkown
HY-153505 ADAMTS-4/5-IN-1 Inhibitor / Unkown
HY-180781 ADAMTS-5-IN-4 Inhibitor / Unkown
HY-P10468 5-FAM-TEGEARGSVILLK(5-TAMRA)K-NH2 / Unkown
HY-RS00305 ADAMTS5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18432 Adamts5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24913 Adamts5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P992336 CRB0017 Inhibitor / Unkown
HY-P992358 GSK2394002 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Adamts5 NCBI NCBI:11096