Xrn2 - 5'-3' exoribonuclease 2 Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 24128

Summary

Predicted to enable exoribonuclease activity, producing 5'-phosphomonoesters; identical protein binding activity; and nucleic acid binding activity. Involved in RNA metabolic process. Acts upstream of or within spermatogenesis. Predicted to be located in aggresome; nucleolus; and nucleoplasm. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in adenoid cystic carcinoma and lung Cancer. Orthologous to human XRN2 (5'-3' exoribonuclease 2). [provided by Alliance of Genome Resources, Apr 2022]

Xrn2 Products (3)

mRNA Protein Name
NM_001356402.1 NP_001343331.1 5'-3' exoribonuclease 2 isoform 2
NM_001356403.1 NP_001343332.1 5'-3' exoribonuclease 2 isoform 3
NM_011917.3 NP_036047.2 5'-3' exoribonuclease 2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
22767893 MGI
Biological Process GO Annotation Evidence References Source
involved in RNA metabolic process IGI
IGI: Inferred from genetic interaction
7885830 MGI
involved in spermatogenesis IEP
IEP: Inferred from expression pattern
7885830 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

5'-3' exoribonuclease 2

  • protein Dhm1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-173593 Adenosine-3',5'-bisphosphate Inhibitor / Unkown
HY-RS15903 XRN2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20840 Xrn2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27354 Xrn2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Xrn2 NCBI NCBI:22803