Ak2 - adenylate kinase 2 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24184

Summary

Enables adenylate kinase activity. Contributes to nucleobase-containing compound kinase activity. Involved in several processes, including oxidative phosphorylation; purine nucleotide metabolic process; and response to thyroid hormone. Located in cytosol; mitochondrial intermembrane space; and nucleus. Biomarker of temporal lobe epilepsy. Human ortholog(s) of this gene implicated in reticular dysgenesis. Orthologous to human AK2 (adenylate kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Ak2 Products (2)

mRNA Protein Name
NM_001033967.2 NP_001029139.1 adenylate kinase 2, mitochondrial isoform b
NM_030986.2 NP_112248.2 adenylate kinase 2, mitochondrial isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables adenylate kinase activity IDA
IDA: Inferred from direct assay
19049516 RGD
contributes to nucleobase-containing compound kinase activity IDA
IDA: Inferred from direct assay
19049516 RGD
Biological Process GO Annotation Evidence References Source
involved in ADP biosynthetic process IDA
IDA: Inferred from direct assay
5123889 RGD
involved in AMP metabolic process IDA
IDA: Inferred from direct assay
5010295 RGD
involved in dATP metabolic process IDA
IDA: Inferred from direct assay
5010295 RGD
involved in liver development IEP
IEP: Inferred from expression pattern
5123889 RGD
involved in oxidative phosphorylation IEP
IEP: Inferred from expression pattern
18423391 RGD
involved in response to thyroid hormone IEP
IEP: Inferred from expression pattern
21563808 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

adenylate kinase 2, mitochondrial

  • AK 2

  • ATP-AMP transphosphorylase 2

  • ATP:AMP phosphotransferase

  • adenylate monophosphate kinase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (12)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-133870 Itaconate-alkyne 98.01% Unkown
HY-118674 AK-2-38 Antagonist / Unkown
HY-161512 hAChE/hBACE-1-IN-4 Inhibitor / Unkown
HY-174999 JAK3-IN-18 Inhibitor / Unkown
HY-178936 JAK2-IN-15 Inhibitor / Unkown
HY-RS00506 AK2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04243 EIF2AK2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174720 Human EIF2AK2 mRNA / Unkown
HY-RS18207 Eif2ak2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18730 Ak2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24684 Eif2ak2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25217 Ak2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ak2 NCBI NCBI:204