Calca - calcitonin-related polypeptide alpha Gene

Also Known as CAL6; CGRP; Cal1; Calc; RATCAL6; calcitonin

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24241

Summary

Predicted to enable Calcitonin receptor binding activity and identical protein binding activity. Involved in several processes, including cellular response to nerve growth factor stimulus; cellular response to tumor necrosis factor; and vasodilation. Located in several cellular components, including axon; extracellular space; and neuronal cell body. Used to study acute necrotizing pancreatitis; ischemia; and stomach disease. Biomarker of prediabetes syndrome and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in migraine and osteoporosis. Orthologous to human CALCA (Calcitonin related polypeptide alpha). [provided by Alliance of Genome Resources, Apr 2022]

Calca Products (3)

mRNA Protein Name
NM_001033955.1 NP_001029127.1 calcitonin gene-related peptide 1 isoform Cgrp preproprotein
NM_001033956.1 NP_001029128.1 calcitonin gene-related peptide 1 isoform Cgrp preproprotein
NM_017338.2 NP_059034.1 calcitonin gene-related peptide 1 isoform Calca preproprotein

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in cellular response to nerve growth factor stimulus IEP
IEP: Inferred from expression pattern
21958434 RGD
involved in cellular response to tumor necrosis factor IEP
IEP: Inferred from expression pattern
21958434 RGD
involved in negative regulation of blood pressure IMP
IMP: Inferred from mutant phenotype
11230364 RGD
involved in negative regulation of smooth muscle contraction IMP
IMP: Inferred from mutant phenotype
11230364 RGD
involved in vasodilation IDA
IDA: Inferred from direct assay
12903912 RGD
Cellular Component GO Annotation Evidence References Source
located in axon IDA
IDA: Inferred from direct assay
11836000 RGD
located in extracellular space IDA
IDA: Inferred from direct assay
11208722 RGD
is active in hippocampal mossy fiber to CA3 synapse IDA
IDA: Inferred from direct assay
9383204 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
11836000 RGD
is active in neuronal dense core vesicle IDA
IDA: Inferred from direct assay
9383204 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

calcitonin gene-related peptide 1

  • CGRP-I

  • alpha-type CGRP

  • calcitonin gene-related peptide I

  • calcitonin/calcitonin-related polypeptide, alpha

  • procalcitonin

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01828 CALCA Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18268 Calca Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24746 Calca Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Calca NCBI NCBI:796