Igf2 - insulin-like growth factor 2 Gene

Also Known as IGFII; RNIGF2

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24483

Summary

Predicted to enable protein serine/threonine kinase activator activity and signaling receptor binding activity. Involved in several processes, including cellular response to mechanical stimulus; positive regulation of blood vessel endothelial cell migration; and positive regulation of vascular endothelial cell proliferation. Located in extracellular space. Used to study osteoporosis. Biomarker of several diseases, including alcoholic neuropathy; brain infarction; congenital diaphragmatic hernia; diabetes mellitus (multiple); and hepatocellular carcinoma. Human ortholog(s) of this gene implicated in Silver-Russell syndrome; choriocarcinoma; hepatocellular carcinoma; and rheumatoid arthritis. Orthologous to human IGF2 (Insulin like growth factor 2). [provided by Alliance of Genome Resources, Apr 2022]

Igf2 Products (3)

mRNA Protein Name
NM_001190162.1 NP_001177091.1 insulin-like growth factor II isoform 2 preproprotein
NM_001190163.1 NP_001177092.1 insulin-like growth factor II isoform 2 preproprotein
NM_031511.2 NP_113699.2 insulin-like growth factor II isoform 1 preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
2538475 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to mechanical stimulus IEP
IEP: Inferred from expression pattern
20695079 RGD
involved in female pregnancy IEP
IEP: Inferred from expression pattern
19776249 RGD
involved in memory IMP
IMP: Inferred from mutant phenotype
21270887 RGD
involved in negative regulation of natural killer cell mediated cytotoxicity IDA
IDA: Inferred from direct assay
9021955 RGD
involved in positive regulation of angiogenesis IGI
IGI: Inferred from genetic interaction
28735866 RGD
involved in positive regulation of blood vessel endothelial cell migration IGI
IGI: Inferred from genetic interaction
28735866 RGD
involved in positive regulation of steroid hormone biosynthetic process IDA
IDA: Inferred from direct assay
17023532 RGD
involved in positive regulation of vascular endothelial cell proliferation IGI
IGI: Inferred from genetic interaction
28735866 RGD
involved in response to estradiol IEP
IEP: Inferred from expression pattern
18946176 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
18505416 RGD
involved in response to nicotine IDA
IDA: Inferred from direct assay
19494366 RGD
involved in response to nicotine IEP
IEP: Inferred from expression pattern
19494366 RGD
involved in response to nutrient levels IEP
IEP: Inferred from expression pattern
17626604 RGD
involved in response to organic cyclic compound IDA
IDA: Inferred from direct assay
17407073 RGD
involved in response to xenobiotic stimulus IDA
IDA: Inferred from direct assay
18778817 RGD
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
6390212 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

insulin-like growth factor II

  • IGF-II

  • Insulin-like growth factor II (somatomedin A)

  • MSA

  • insulin-like growth factor II (IGF-II)

  • multiplication-stimulating activity

  • multiplication-stimulating polypeptide

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive MoleculesInhibitory Antibodies (4)
Cat. No. Product Name Effect
Purity Phase
HY-P99294 Ganitumab Inhibitor 96.00% Phase 3
HY-P99274 Xentuzumab Antagonist 99.71% Phase 2
HY-P99284 Dalotuzumab 97.43% Phase 2
HY-P991253 BIIB022 Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (27)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-153274 CWI1-2 Inducer 98.85% Unkown
HY-144873 AVJ16 Inducer 99.60% Unkown
HY-174228 I3IN-002 99.35% Unkown
HY-124447 BTYNB 98.0% Unkown
HY-153274A CWI1-2 hydrochloride Inducer 98.27% Unkown
HY-156110 IGF2BP1-IN-1 Inhibitor 99.94% Unkown
HY-115449 Chromeceptin 99.80% Unkown
HY-176471 IGF2BP3-IN-1 Inhibitor 99.05% Unkown
HY-RS06618 IGF2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06619 IGF2BP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06620 IGF2BP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06621 IGF2BP3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06622 IGF2R Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17518 Igf2bp3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-181666 Z971169476 / Unkown
HY-E70730 INSR Recombinant Human Active Protein Kinase / Unkown
HY-RS06839 INS-IGF2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174653 Human IGF2 mRNA / Unkown
HY-RS16571 Igf2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16822 Igf2bp2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16849 Igf2bp1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17981 Igf2r Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23004 Igf2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23262 Igf2bp2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23290 Igf2bp1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23975 Igf2bp3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24452 Igf2r Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Igf2 NCBI NCBI:3481
Mus musculus Igf2 NCBI NCBI:16002
Macaca mulatta Igf2 NCBI NCBI:710802