2. Apoptosis
  3. Apoptosis
  4. CWI1-2 hydrochloride

CWI1-2 hydrochloride is an IGF2BP2 inhibitor that binds IGF2BP2 and inhibits its interaction with m6A-modified target transcripts, induces apoptosis and differentiation, and shows promising anti-leukemic effects.

For research use only. We do not sell to patients.

CWI1-2 hydrochloride Chemical Structure

CWI1-2 hydrochloride Chemical Structure

CAS No. : 2408590-37-2

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CWI1-2 hydrochloride Related Antibodies

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Description

CWI1-2 hydrochloride is an IGF2BP2 inhibitor that binds IGF2BP2 and inhibits its interaction with m6A-modified target transcripts, induces apoptosis and differentiation, and shows promising anti-leukemic effects[1].

In Vitro

CWI1-2 (0-1 μM, 24 h) hydrochloride has good anti-leukemic efficacy[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CWI1-2 hydrochloride Related Antibodies

Apoptosis Analysis[1]

Cell Line: MonoMac6, MOLM13
Concentration: 0-1 μM
Incubation Time: 24 h
Result: Induced significant cell differentiation and apoptosis in a concentration-dependent manner in IGF2BP2-high cells but not in IGF2BP2-low cells.
Reduced Gln uptake and impaired mitochondrial function, resulting in reduced ATP production in AML cells.
Significantly inhibited the colony-forming ability of MA9-induced leukemic mouse blasts and greatly impairs the self-renewal of LSC/LIC.
In Vivo

CWI1-2 (5 mg/kg, i.v., once daily, 7-10 days) hydrochloride can significantly delay the onset of leukemia and prolong the survival time of BMT recipient B6.SJL (CD45.1) mice without any loss in body weight[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

556.23

Formula

C22H18Cl4N6O3
CAS No.
SMILES

OC(C=C1)=C(C=C1Cl)/C=N/N=C(N/N=C\C(C=C2Cl)=C(C=C2)O)\N/N=C/C(C=C3Cl)=C(C=C3)O.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CWI1-2 hydrochloride Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CWI1-22408590-37-2ApoptosisIGF2BP2m6Aapoptosisdifferentiationanti-leukemicInhibitorinhibitorinhibit

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CWI1-2 hydrochloride
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HY-153274A
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