CWI1-2 hydrochloride
Based on 7 publication(s) in Google Scholar
CWI1-2 hydrochloride is an IGF2BP2 inhibitor that binds IGF2BP2 and inhibits its interaction with m6A-modified target transcripts, induces apoptosis and differentiation, and shows promising anti-leukemic effects.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 98.27%
- CAS. Nr.: 2408590-37-2
- Formel: C22H18Cl4N6O3
- Molecular Weight:556.23
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Speicherung:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) CWI1-2 hydrochloride
More- Nat Commun. 2025 Feb 7;16(1):1087. [Abstract]
- J Adv Res. 2026 Jun 5:S2090-1232(26)00460-1. [Abstract]
- Cancer Lett. 2026 Jul 24:218761.
- Int J Biol Sci. 2026 Jan 1;22(1):142-160. [Abstract]
- Cell Rep. 2025 Oct 15;44(10):116438. [Abstract]
- Biochem Pharmacol. 2026 Jun 25:252:118198. [Abstract]
- SSRN. 2025 Apr 10.
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Cell Imaging/Staining
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Bio/Physico-chemical Assay
Biologische Aktivität
Beschreibung
In Vitro
CWI1-2 (0-1 μM, 24 h) hydrochloride has good anti-leukemic efficacy[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MonoMac6, MOLM13
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Concentration:0-1 μM
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Incubation Time:24 h
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Result:Induced significant cell differentiation and apoptosis in a concentration-dependent manner in IGF2BP2-high cells but not in IGF2BP2-low cells.
Reduced Gln uptake and impaired mitochondrial function, resulting in reduced ATP production in AML cells.
Significantly inhibited the colony-forming ability of MA9-induced leukemic mouse blasts and greatly impairs the self-renewal of LSC/LIC.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 2408590-37-2
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Appearance Solid
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Molecular Weight 556.23
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Formel C22H18Cl4N6O3
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Color Light yellow to yellow
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SMILES
OC(C=C1)=C(C=C1Cl)/C=N/N=C(N/N=C\C(C=C2Cl)=C(C=C2)O)\N/N=C/C(C=C3Cl)=C(C=C3)O.[H]Cl
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (7)
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Journal Impact Factor
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Most Recent
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Nat Commun
Targeting eEF1A reprograms translation and uncovers broad-spectrum antivirals against cap or m6A protein synthesis routes. [Abstract]2025 Feb 7;16(1):1087. PMID: 39920115
CWI1-2 hydrochloride purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 7;16(1):1087. [Abstract]
IGF2BP2 inhibitor CWI1-2 (1-5 μM) reduced HIV-1 luciferase expression in Vero E6 cells.
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J Adv Res
PAD4-mediated citrullination of IGF2BP2 stabilizes MCM mRNAs to drive intrahepatic cholangiocarcinoma progression. [Abstract]2026 Jun 5:S2090-1232(26)00460-1. PMID: 42250722 -
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Int J Biol Sci
H3K27 Acetylation-driven IGF2BP2 Mutates during the Aging of MSCs, thereby Influencing Osteogenic Differentiation and Bone Aging. [Abstract]2026 Jan 1;22(1):142-160. PMID: 41362747
CWI1-2 hydrochloride purchased from MedChemExpress. Usage Cited in: Int J Biol Sci. 2026 Jan 1;22(1):142-160. [Abstract]
CWI1-2 (1 μM; 48 h) significantly reduced protein levels of HMGA1 in senescent MSCs.
CWI1-2 hydrochloride purchased from MedChemExpress. Usage Cited in: Int J Biol Sci. 2026 Jan 1;22(1):142-160. [Abstract]
CWI1-2 (1 μM; 48 h) alleviated senescence in MSCs, as evidenced by reduced SA-β-gal positivity.
CWI1-2 hydrochloride purchased from MedChemExpress. Usage Cited in: Int J Biol Sci. 2026 Jan 1;22(1):142-160. [Abstract]
CWI1-2 (1 μM; 48 h) reduced senescence marker expression in MSCs.
CWI1-2 hydrochloride purchased from MedChemExpress. Usage Cited in: Int J Biol Sci. 2026 Jan 1;22(1):142-160. [Abstract]
CWI1-2 (1 μM; 48 h) decreased the fluorescence intensity of IGF2BP2 and Hmga1 mRNA and reduced their co-localization in MCSs.
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Cell Rep
The m6A reader IGF2BP2 promotes homologous recombination-mediated DNA repair by eliminating DNA-RNA hybrids. [Abstract]2025 Oct 15;44(10):116438. PMID: 41100254 -
Biochem Pharmacol
Chlorogenic acid promotes macrophage phagocytosis through the METTL3-SIRPA axis in an m6A-dependent manner for colon cancer therapy. [Abstract]2026 Jun 25:252:118198. PMID: 42349614 -
Lösungsmittel & Löslichkeit
In Vitro:
DMSO : 50 mg/mL (89.89 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 1.25 mg/mL (2.25 mM); Clear solution
This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (12.5 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Reinheit & Dokumentation
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Data Sheet (279 KB)
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SDS (416 KB)
- English - EN (416 KB)
- Français - FR (416 KB)
- Deutsch - DE (416 KB)
- Norwegian - NO (416 KB)
- Español - ES (416 KB)
- Swedish - SV (416 KB)
- Italian - IT (416 KB)
- Korean - KR (416 KB)
- Portuguese - PT (416 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 1.7978 mL | 8.9891 mL | 17.9782 mL | 44.9454 mL |
| 5 mM | 0.3596 mL | 1.7978 mL | 3.5956 mL | 8.9891 mL | |
| 10 mM | 0.1798 mL | 0.8989 mL | 1.7978 mL | 4.4945 mL | |
| 15 mM | 0.1199 mL | 0.5993 mL | 1.1985 mL | 2.9964 mL | |
| 20 mM | 0.0899 mL | 0.4495 mL | 0.8989 mL | 2.2473 mL | |
| 25 mM | 0.0719 mL | 0.3596 mL | 0.7191 mL | 1.7978 mL | |
| 30 mM | 0.0599 mL | 0.2996 mL | 0.5993 mL | 1.4982 mL | |
| 40 mM | 0.0449 mL | 0.2247 mL | 0.4495 mL | 1.1236 mL | |
| 50 mM | 0.0360 mL | 0.1798 mL | 0.3596 mL | 0.8989 mL | |
| 60 mM | 0.0300 mL | 0.1498 mL | 0.2996 mL | 0.7491 mL | |
| 80 mM | 0.0225 mL | 0.1124 mL | 0.2247 mL | 0.5618 mL |
CWI1-2 hydrochloride Related Classifications
HY-153274A Related Classifications
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