Il6r - interleukin 6 receptor Gene

Also Known as IL6R1; Il6ra

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24499

Summary

Predicted to enable several functions, including cytokine binding activity; cytokine receptor activity; and protein homodimerization activity. Predicted to contribute to ciliary neurotrophic factor receptor activity and interleukin-6 receptor binding activity. Involved in several processes, including response to cAMP; response to gamma radiation; and response to lipopolysaccharide. Located in extracellular space and neuronal cell body membrane. Biomarker of several diseases, including congestive heart failure; mental depression; orchitis; sciatic neuropathy; and visual epilepsy. Human ortholog(s) of this gene implicated in Alzheimer's disease; Huntington's disease; hyper IgE syndrome; obesity; and stomach Cancer. Orthologous to human IL6R (interleukin 6 receptor). [provided by Alliance of Genome Resources, Apr 2022]

Il6r Products (1)

mRNA Protein Name
NM_017020.3 NP_058716.2 interleukin-6 receptor subunit alpha precursor

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in developmental growth IMP
IMP: Inferred from mutant phenotype
23855552 RGD
involved in positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
19961020 RGD
involved in response to cAMP IEP
IEP: Inferred from expression pattern
7814800 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
15084893 RGD
involved in response to gamma radiation IEP
IEP: Inferred from expression pattern
14751512 RGD
involved in response to glucocorticoid IEP
IEP: Inferred from expression pattern
7814800 RGD
involved in response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
7814800 RGD
involved in response to peptide hormone IEP
IEP: Inferred from expression pattern
11171594 RGD
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
11448096 RGD
located in neuronal cell body membrane IDA
IDA: Inferred from direct assay
8921254 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

interleukin-6 receptor subunit alpha

  • IL-6 receptor subunit alpha

  • IL-6R 1

  • IL-6R subunit alpha

  • IL-6R-alpha

  • IL-6RA

  • interleukin 6 receptor, alpha

Recombinant Il6r Proteins

Cat. No. Product Name Accession Purity
HY-P73224 IL-6R Protein, Rat (HEK293, His) NP_058716.2 (L20-P364) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P73876 IL-6R Protein, Rat (HEK293, Fc) NP_058716.2 (L20-P364) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Inhibitory Antibodies (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P9917 Tocilizumab Antagonist 99.67% Unkown
HY-P9916 Sarilumab Inhibitor 99.36% Unkown
HY-P99112 Satralizumab Inhibitor 99.82% Unkown

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-P10284 S7 98.25% Phase 4
Inhibitory Antibodies (4)
Cat. No. Product Name Effect
Purity Phase
HY-P990012 Vamikibart Inhibitor ≥99.0% Phase 3
HY-P99702 Levilimab Inhibitor 97.52% Phase 3
HY-P99385 Vobarilizumab Inhibitor 99.9% Phase 2
HY-P991519 VDJ001 Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P0317 IL-6R (352-363) 96.21% Unkown
HY-177063 IL-6-IN-2 Inhibitor 99.95% Unkown
HY-182273 DM243 / Unkown
HY-182274 DM245 / Unkown
HY-RS06777 IL6R Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174599 Human IL6R mRNA / Unkown
HY-RS23587 Il6r Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990211 Anti-Mouse IL-6R Antibody (15A7) Inhibitor 99.79% Unkown
HY-P991602 NI-1201 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Il6r NCBI NCBI:3570