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Nos1 - nitric oxide synthase 1 Gene

Also Known as bNOS

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 24598

About Nos1

Primary_assembly 12: 38,626,714-38,710,945 reverse strand.mRatBN7.2:CM026985.1

This gene has 3 transcripts (splice variants), 198 orthologues, 5 paralogues and is associated with 72 phenotypes. Biased expression in Adrenal (RPKM 54.3), Muscle (RPKM 48.6) and 4 other tissues.

Summary

Enables several functions, including ATPase binding activity; nucleotide binding activity; and transition metal ion binding activity. Involved in several processes, including blood vessel diameter maintenance; regulation of cation transmembrane transport; and regulation of neuron death. Located in several cellular components, including azurophil granule; nuclear membrane; and sarcolemma. Part of protein-containing complex. Is active in glutamatergic synapse and postsynaptic density, intracellular component. Used to study several diseases, including acute necrotizing pancreatitis; brain ischemia (multiple); end stage renal disease; impotence; and portal hypertension. Biomarker of several diseases, including brain disease (multiple); cardiomyopathy (multiple); hypertension (multiple); kidney failure (multiple); and retinal disease (multiple). Human ortholog(s) of this gene implicated in Alzheimer's disease; Parkinson's disease; asthma; cystic fibrosis; and hypertrophic pyloric stenosis. Orthologous to human NOS1 (nitric oxide synthase 1). [provided by Alliance of Genome Resources, Apr 2022]

Nos1 Products (1)

mRNA	Protein	Name
NM_052799.2	NP_434686.2	nitric oxide synthase, brain

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ATPase binding	IPI IPI: Inferred from physical interaction	11591728	RGD
enables FMN binding	IDA IDA: Inferred from direct assay	1383204	RGD
enables NADP binding	IDA IDA: Inferred from direct assay	17029414	RGD
enables NADPH binding	IDA IDA: Inferred from direct assay	14966111	RGD
enables cadmium ion binding	IDA IDA: Inferred from direct assay	17029414	RGD
enables calcium-dependent protein binding	IPI IPI: Inferred from physical interaction	23549614	RGD
enables calmodulin binding	IDA IDA: Inferred from direct assay	14966111	RGD
enables enzyme binding	IPI IPI: Inferred from physical interaction	16537391	RGD
enables flavin adenine dinucleotide binding	IDA IDA: Inferred from direct assay	1383204	RGD
enables heme binding	IDA IDA: Inferred from direct assay	1383204	RGD
enables identical protein binding	IPI IPI: Inferred from physical interaction	17347455	RGD
enables nitric-oxide synthase activity	IDA IDA: Inferred from direct assay	1383204	RGD
enables phosphoprotein binding	IPI IPI: Inferred from physical interaction	11590170	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	11086993	RGD
enables scaffold protein binding	IPI IPI: Inferred from physical interaction	18591664	RGD
enables sodium channel regulator activity	IMP IMP: Inferred from mutant phenotype	18591664	RGD
enables transmembrane transporter binding	IPI IPI: Inferred from physical interaction	18591664	RGD
enables zinc ion binding	IDA IDA: Inferred from direct assay	10954720	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in arginine catabolic process	IDA IDA: Inferred from direct assay	1383204	RGD
involved in behavioral response to cocaine	IMP IMP: Inferred from mutant phenotype	23579428	RGD
involved in cellular response to epinephrine stimulus	IMP IMP: Inferred from mutant phenotype	19278978	RGD
involved in cellular response to mechanical stimulus	IMP IMP: Inferred from mutant phenotype	23619128	RGD
involved in establishment of protein localization	IDA IDA: Inferred from direct assay	11590170	RGD
involved in female pregnancy	IEP IEP: Inferred from expression pattern	20630934	RGD
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	20596694	RGD
involved in negative regulation of blood pressure	IMP IMP: Inferred from mutant phenotype	15331368	RGD
involved in negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	20338922	RGD
involved in negative regulation of cytosolic calcium ion concentration	IMP IMP: Inferred from mutant phenotype	23172925	RGD
involved in negative regulation of hepatic stellate cell contraction	IDA IDA: Inferred from direct assay	10727442	RGD
involved in negative regulation of insulin secretion	IMP IMP: Inferred from mutant phenotype	17130471	RGD
involved in negative regulation of iron ion transmembrane transport	IMP IMP: Inferred from mutant phenotype	14752097	RGD
involved in negative regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	14752097	RGD
involved in negative regulation of vasoconstriction	IMP IMP: Inferred from mutant phenotype	23640592	RGD
involved in nitric oxide biosynthetic process	IDA IDA: Inferred from direct assay	1383204	RGD
involved in nitric oxide metabolic process	IEP IEP: Inferred from expression pattern	31489946	RGD
involved in nitric oxide-cGMP-mediated signaling	IMP IMP: Inferred from mutant phenotype	19278978	RGD
involved in peptidyl-cysteine S-nitrosylation	IDA IDA: Inferred from direct assay	18591664	RGD
acts upstream of positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	19278978	RGD
involved in positive regulation of long-term synaptic potentiation	IMP IMP: Inferred from mutant phenotype	23579428	RGD
involved in positive regulation of sodium ion transmembrane transport	IMP IMP: Inferred from mutant phenotype	18591664	RGD
involved in response to activity	IEP IEP: Inferred from expression pattern	19793134	RGD
involved in response to estrogen	IDA IDA: Inferred from direct assay	17553983	RGD
involved in response to ethanol	IEP IEP: Inferred from expression pattern	12581836	RGD
involved in response to hypoxia	IEP IEP: Inferred from expression pattern	16276418	RGD
involved in response to lead ion	IEP IEP: Inferred from expression pattern	19524414	RGD
involved in response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	20724006	RGD
involved in response to nicotine	IEP IEP: Inferred from expression pattern	21050840	RGD
involved in response to nitric oxide	IEP IEP: Inferred from expression pattern	20473255	RGD
involved in response to nutrient levels	IEP IEP: Inferred from expression pattern	20079408	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	17611313	RGD
involved in response to peptide hormone	IMP IMP: Inferred from mutant phenotype	20181617	RGD
involved in response to vitamin E	IEP IEP: Inferred from expression pattern	17200156	RGD
involved in vasodilation	IMP IMP: Inferred from mutant phenotype	17291465	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in azurophil granule	IDA IDA: Inferred from direct assay	16387842	RGD
located in cell periphery	IDA IDA: Inferred from direct assay	23549614	RGD
located in cytoplasm	IDA IDA: Inferred from direct assay	11590170	RGD
located in dendrite	IDA IDA: Inferred from direct assay	12526033	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	12388603	RGD
located in mitochondrial outer membrane	IDA IDA: Inferred from direct assay	12526033	RGD
located in mitochondrion	IDA IDA: Inferred from direct assay	16537391	RGD
located in nuclear membrane	IDA IDA: Inferred from direct assay	16387842	RGD
located in nucleus	IDA IDA: Inferred from direct assay	11590170	RGD
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	17027776	RGD
located in photoreceptor inner segment	IDA IDA: Inferred from direct assay	17027776	RGD
is active in postsynaptic density, intracellular component	IDA IDA: Inferred from direct assay	12388603	RGD
is active in postsynaptic specialization, intracellular component	IDA IDA: Inferred from direct assay	12388603	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	18591664	RGD
located in sarcolemma	IDA IDA: Inferred from direct assay	7527495	RGD
located in secretory granule	IDA IDA: Inferred from direct assay	11375331	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Nos1 Protein Structure

PDZ_signaling

NOS_oxygenase_euk

Flavodoxin_1

Nitric_oxide_synthase

0
300
600
900
1200
1532 a.a.

Protein Preferred Names	Protein Names
nitric oxide synthase, brain	N-NOS NC-NOS NOS type I constitutive NOS nNOS neuronal NOS nitric oxidase synthase nitric oxide synthase 1, neuronal peptidyl-cysteine S-nitrosylase NOS1

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-18732	L-NMMA	Inhibitor	99.43%	Phase 4

Pre-clinical Phase

Bioactive Molecules (14)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N6607	Tryptanthrin		99.89%	Unkown
HY-130452	NOS1-IN-1	Inhibitor	95.0%	Unkown
HY-107720	ARL 17477	Inhibitor	99.02%	Unkown
HY-RS09433	NOS1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-12117	L-NIL hydrochloride	Inhibitor	/	Unkown
HY-124996	(Rac)-ZLc-002	Inhibitor	98.11%	Unkown
HY-101304	S-Isopropylisothiourea hydrobromide	Inhibitor	98.0%	Unkown
HY-RS09021	NANOS1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS09434	Nos1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS09435	Nos1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS09436	NOS1AP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19265	Nos1ap Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21891	Nanos1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25754	Nos1ap Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nos1	NCBI	NCBI:4842